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Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk facto...

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Autores principales: Hollander, Jonathan A., Cory-Slechta, Deborah A., Jacka, Felice N., Szabo, Steven T., Guilarte, Tomás R., Bilbo, Staci D., Mattingly, Carolyn J., Moy, Sheryl S., Haroon, Ebrahim, Hornig, Mady, Levin, Edward D., Pletnikov, Mikhail V., Zehr, Julia L., McAllister, Kimberly A., Dzierlenga, Anika L., Garton, Amanda E., Lawler, Cindy P., Ladd-Acosta, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234981/
https://www.ncbi.nlm.nih.gov/pubmed/32109936
http://dx.doi.org/10.1038/s41386-020-0648-5
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author Hollander, Jonathan A.
Cory-Slechta, Deborah A.
Jacka, Felice N.
Szabo, Steven T.
Guilarte, Tomás R.
Bilbo, Staci D.
Mattingly, Carolyn J.
Moy, Sheryl S.
Haroon, Ebrahim
Hornig, Mady
Levin, Edward D.
Pletnikov, Mikhail V.
Zehr, Julia L.
McAllister, Kimberly A.
Dzierlenga, Anika L.
Garton, Amanda E.
Lawler, Cindy P.
Ladd-Acosta, Christine
author_facet Hollander, Jonathan A.
Cory-Slechta, Deborah A.
Jacka, Felice N.
Szabo, Steven T.
Guilarte, Tomás R.
Bilbo, Staci D.
Mattingly, Carolyn J.
Moy, Sheryl S.
Haroon, Ebrahim
Hornig, Mady
Levin, Edward D.
Pletnikov, Mikhail V.
Zehr, Julia L.
McAllister, Kimberly A.
Dzierlenga, Anika L.
Garton, Amanda E.
Lawler, Cindy P.
Ladd-Acosta, Christine
author_sort Hollander, Jonathan A.
collection PubMed
description The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms—synaptic dysfunction, immune alterations, and gut–brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease.
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spelling pubmed-72349812020-05-20 Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease Hollander, Jonathan A. Cory-Slechta, Deborah A. Jacka, Felice N. Szabo, Steven T. Guilarte, Tomás R. Bilbo, Staci D. Mattingly, Carolyn J. Moy, Sheryl S. Haroon, Ebrahim Hornig, Mady Levin, Edward D. Pletnikov, Mikhail V. Zehr, Julia L. McAllister, Kimberly A. Dzierlenga, Anika L. Garton, Amanda E. Lawler, Cindy P. Ladd-Acosta, Christine Neuropsychopharmacology Review Article The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, and their potential interactions with genetic susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering the impact of chemical risk factors acting alone and in concert with genetic risk, and point to the potential role of epigenetics in mediating exposure effects on transcription of genes implicated in mental disorders. We highlight recent examples of research in nongenetic risk factors in psychiatric disorders that point to potential shared biological mechanisms—synaptic dysfunction, immune alterations, and gut–brain interactions. We outline new tools and resources that can be harnessed for the study of environmental factors in psychiatric disorders. These tools, combined with emerging experimental evidence, suggest that there is a need to broadly incorporate environmental exposures in psychiatric research, with the ultimate goal of identifying modifiable risk factors and informing new treatment strategies for neuropsychiatric disease. Springer International Publishing 2020-02-28 2020-06 /pmc/articles/PMC7234981/ /pubmed/32109936 http://dx.doi.org/10.1038/s41386-020-0648-5 Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. This article is published with open access 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Hollander, Jonathan A.
Cory-Slechta, Deborah A.
Jacka, Felice N.
Szabo, Steven T.
Guilarte, Tomás R.
Bilbo, Staci D.
Mattingly, Carolyn J.
Moy, Sheryl S.
Haroon, Ebrahim
Hornig, Mady
Levin, Edward D.
Pletnikov, Mikhail V.
Zehr, Julia L.
McAllister, Kimberly A.
Dzierlenga, Anika L.
Garton, Amanda E.
Lawler, Cindy P.
Ladd-Acosta, Christine
Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title_full Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title_fullStr Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title_full_unstemmed Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title_short Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
title_sort beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234981/
https://www.ncbi.nlm.nih.gov/pubmed/32109936
http://dx.doi.org/10.1038/s41386-020-0648-5
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