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Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study
The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235014/ https://www.ncbi.nlm.nih.gov/pubmed/32424139 http://dx.doi.org/10.1038/s41398-020-0804-z |
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author | Alemany-Navarro, María Cruz, Raquel Real, Eva Segalàs, Cinto Bertolín, Sara Rabionet, Raquel Carracedo, Ángel Menchón, Jose M. Alonso, Pino |
author_facet | Alemany-Navarro, María Cruz, Raquel Real, Eva Segalàs, Cinto Bertolín, Sara Rabionet, Raquel Carracedo, Ángel Menchón, Jose M. Alonso, Pino |
author_sort | Alemany-Navarro, María |
collection | PubMed |
description | The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this study, we analyze the genomic markers, genes, gene ontology and biological pathways associated with the presence of aggressive/checking, symmetry/order, contamination/cleaning, hoarding, and sexual/religious symptoms, as assessed via the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) in 399 probands. Logistic regression analyses were performed at the single-nucleotide polymorphism (SNP) level. Gene-based and enrichment analyses were carried out for common (SNPs) and rare variants. No SNP was associated with any dimension at a genome-wide level (p < 5 × 10(−8)). Gene-based analyses showed one gene to be associated with hoarding (SETD3, p = 1.89 × 10(−08)); a gene highly expressed in the brain and which plays a role in apoptotic processes and transcriptomic changes, and another gene associated with aggressive symptoms (CPE; p = 4.42 × 10(−6)), which is involved in neurotrophic functions and the synthesis of peptide hormones and neurotransmitters. Different pathways or biological processes were represented by genes associated with aggressive (zinc ion response and lipid metabolism), order (lipid metabolism), sexual/religious (G protein-mediated processes) and hoarding (metabolic processes and anion transport) symptoms after FDR correction; while no pathway was associated with contamination. Specific genomic bases were found for each dimension assessed, especially in the enrichment analyses. Further research with larger samples and different techniques, such as next-generation sequencing, are needed to better understand the differential genetics of OCD dimensions. |
format | Online Article Text |
id | pubmed-7235014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72350142020-05-20 Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study Alemany-Navarro, María Cruz, Raquel Real, Eva Segalàs, Cinto Bertolín, Sara Rabionet, Raquel Carracedo, Ángel Menchón, Jose M. Alonso, Pino Transl Psychiatry Article The multidimensional nature of obsessive-compulsive disorder (OCD) has been consistently reported. Clinical and biological characteristics have been associated with OCD dimensions in different ways. Studies suggest the existence of specific genetic bases for the different OCD dimensions. In this study, we analyze the genomic markers, genes, gene ontology and biological pathways associated with the presence of aggressive/checking, symmetry/order, contamination/cleaning, hoarding, and sexual/religious symptoms, as assessed via the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) in 399 probands. Logistic regression analyses were performed at the single-nucleotide polymorphism (SNP) level. Gene-based and enrichment analyses were carried out for common (SNPs) and rare variants. No SNP was associated with any dimension at a genome-wide level (p < 5 × 10(−8)). Gene-based analyses showed one gene to be associated with hoarding (SETD3, p = 1.89 × 10(−08)); a gene highly expressed in the brain and which plays a role in apoptotic processes and transcriptomic changes, and another gene associated with aggressive symptoms (CPE; p = 4.42 × 10(−6)), which is involved in neurotrophic functions and the synthesis of peptide hormones and neurotransmitters. Different pathways or biological processes were represented by genes associated with aggressive (zinc ion response and lipid metabolism), order (lipid metabolism), sexual/religious (G protein-mediated processes) and hoarding (metabolic processes and anion transport) symptoms after FDR correction; while no pathway was associated with contamination. Specific genomic bases were found for each dimension assessed, especially in the enrichment analyses. Further research with larger samples and different techniques, such as next-generation sequencing, are needed to better understand the differential genetics of OCD dimensions. Nature Publishing Group UK 2020-05-18 /pmc/articles/PMC7235014/ /pubmed/32424139 http://dx.doi.org/10.1038/s41398-020-0804-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Alemany-Navarro, María Cruz, Raquel Real, Eva Segalàs, Cinto Bertolín, Sara Rabionet, Raquel Carracedo, Ángel Menchón, Jose M. Alonso, Pino Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title_full | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title_fullStr | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title_full_unstemmed | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title_short | Looking into the genetic bases of OCD dimensions: a pilot genome-wide association study |
title_sort | looking into the genetic bases of ocd dimensions: a pilot genome-wide association study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235014/ https://www.ncbi.nlm.nih.gov/pubmed/32424139 http://dx.doi.org/10.1038/s41398-020-0804-z |
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