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Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma
In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of glaucoma. There have been experimental studies...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235030/ https://www.ncbi.nlm.nih.gov/pubmed/32424225 http://dx.doi.org/10.1038/s41598-020-65037-6 |
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author | Shin, Da Young Jeon, Soo Ji Park, Hae Young Lopilly Park, Chan Kee |
author_facet | Shin, Da Young Jeon, Soo Ji Park, Hae Young Lopilly Park, Chan Kee |
author_sort | Shin, Da Young |
collection | PubMed |
description | In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of glaucoma. There have been experimental studies to find out the association between autonomic nervous system and ocular growth, but no clinical study yet has evaluated the relationship between them. Therefore, we enrolled 208 open angle glaucoma patients and measured heart-rate-variability(HRV). We used the standard deviation value of the qualified normal to normal intervals (SDNN) parameter of HRV, which is considered an autonomic influence index and characterized the total effect of the regulation of autonomic blood circulation. Patients were classified into the two groups according to SDNN: those with low possibility of autonomic dysfunction (LoAD group) and those with high possibility of autonomic dysfunction (HiAD group). We evaluated myopic features employing a ‘posterior scleral profile’ identified by the disc tilt ratio, disc torsion, fovea-BMO center (FoBMO) angle and peripapapillary area(PPA) to disc ratio. HiAD group showed higher values than LoAD group in posterior scleral deformation profile such like axial length, disc tilt, torsion degree. We suggest the possibility of association between myopic deformation and autonomic dysfunction. |
format | Online Article Text |
id | pubmed-7235030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72350302020-05-26 Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma Shin, Da Young Jeon, Soo Ji Park, Hae Young Lopilly Park, Chan Kee Sci Rep Article In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of glaucoma. There have been experimental studies to find out the association between autonomic nervous system and ocular growth, but no clinical study yet has evaluated the relationship between them. Therefore, we enrolled 208 open angle glaucoma patients and measured heart-rate-variability(HRV). We used the standard deviation value of the qualified normal to normal intervals (SDNN) parameter of HRV, which is considered an autonomic influence index and characterized the total effect of the regulation of autonomic blood circulation. Patients were classified into the two groups according to SDNN: those with low possibility of autonomic dysfunction (LoAD group) and those with high possibility of autonomic dysfunction (HiAD group). We evaluated myopic features employing a ‘posterior scleral profile’ identified by the disc tilt ratio, disc torsion, fovea-BMO center (FoBMO) angle and peripapapillary area(PPA) to disc ratio. HiAD group showed higher values than LoAD group in posterior scleral deformation profile such like axial length, disc tilt, torsion degree. We suggest the possibility of association between myopic deformation and autonomic dysfunction. Nature Publishing Group UK 2020-05-18 /pmc/articles/PMC7235030/ /pubmed/32424225 http://dx.doi.org/10.1038/s41598-020-65037-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shin, Da Young Jeon, Soo Ji Park, Hae Young Lopilly Park, Chan Kee Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title | Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title_full | Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title_fullStr | Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title_full_unstemmed | Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title_short | Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
title_sort | posterior scleral deformation and autonomic dysfunction in normal tension glaucoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235030/ https://www.ncbi.nlm.nih.gov/pubmed/32424225 http://dx.doi.org/10.1038/s41598-020-65037-6 |
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