Progression and Classification of Granular Osmiophilic Material (GOM) Deposits in Functionally Characterized Human NOTCH3 Transgenic Mice

CADASIL is a NOTCH3-associated cerebral small vessel disease. A pathological ultrastructural disease hallmark is the presence of NOTCH3-protein containing deposits called granular osmiophilic material (GOM), in small arteries. How these GOM deposits develop over time and what their role is in diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Gravesteijn, Gido, Munting, Leon P., Overzier, Maurice, Mulder, Aat A., Hegeman, Ingrid, Derieppe, Marc, Koster, Abraham J., van Duinen, Sjoerd G., Meijer, Onno C., Aartsma-Rus, Annemieke, van der Weerd, Louise, Jost, Carolina R., van den Maagdenberg, Arn M. J. M., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235067/
https://www.ncbi.nlm.nih.gov/pubmed/31667734
http://dx.doi.org/10.1007/s12975-019-00742-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235067/
https://www.ncbi.nlm.nih.gov/pubmed/31667734
http://dx.doi.org/10.1007/s12975-019-00742-7

Ejemplares similares