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Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib

Ovarian cancer represents the first cause of mortality from gynecologic malignancies due to frequent chemoresistance occurrence. Increasing the [BH3-only Bim, Puma, Noxa proapoptotic]/[Bcl-x(L), Mcl-1 antiapoptotic] proteins ratio was proven to efficiently kill ovarian carcinoma cells and developmen...

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Detalles Bibliográficos
Autores principales:	Florent, Romane, Weiswald, Louis-Bastien, Lambert, Bernard, Brotin, Emilie, Abeilard, Edwige, Louis, Marie-Hélène, Babin, Guillaume, Poulain, Laurent, N’Diaye, Monique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235085/ https://www.ncbi.nlm.nih.gov/pubmed/32424251 http://dx.doi.org/10.1038/s41419-020-2588-8

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