Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation

Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin gene. The expanded polyglutamine (polyQ) repeat of the encoded protein leads to protein misfolding and aggregation, resulting in increased neuronal cell death. DNAJ co-chaperones play a crucial role in transferring misfold...

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Detalles Bibliográficos
Autores principales: Rodríguez-González, Claudio, Lin, Shiying, Arkan, Sertan, Hansen, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235262/
https://www.ncbi.nlm.nih.gov/pubmed/32424160
http://dx.doi.org/10.1038/s41598-020-65046-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235262/
https://www.ncbi.nlm.nih.gov/pubmed/32424160
http://dx.doi.org/10.1038/s41598-020-65046-5

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