Cargando…

Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo

The closed-loop brain stimulation technique plays a key role in neural network information processing and therapies of neurological diseases. Transcranial ultrasound stimulation (TUS) is an established neuromodulation method for the neural oscillation in animals or human. All available TUS systems p...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Huifang, Yuan, Yi, Wang, Xingran, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235408/
https://www.ncbi.nlm.nih.gov/pubmed/32477055
http://dx.doi.org/10.3389/fnins.2020.00445
_version_ 1783535961383108608
author Yang, Huifang
Yuan, Yi
Wang, Xingran
Li, Xin
author_facet Yang, Huifang
Yuan, Yi
Wang, Xingran
Li, Xin
author_sort Yang, Huifang
collection PubMed
description The closed-loop brain stimulation technique plays a key role in neural network information processing and therapies of neurological diseases. Transcranial ultrasound stimulation (TUS) is an established neuromodulation method for the neural oscillation in animals or human. All available TUS systems provide brain stimulation in an open-loop pattern. In this study, we developed a closed-loop transcranial ultrasound stimulation (CLTUS) system for real-time non-invasive neuromodulation in vivo. We used the CLTUS system to modulate the neural activities of the hippocampus of a wild-type mouse based on the phase of the theta rhythm recorded at the ultrasound-targeted location. In addition, we modulated the hippocampus of a temporal lobe epilepsy (TLE) mouse. The ultrasound stimulation increased the absolute power and reduced the relative power of the theta rhythm, which were independent of the specific phase of the theta rhythm. Compared with those of a sham stimulation, the latency of epileptic seizures was significantly increased, while the epileptic seizure duration was significantly decreased under the CLTUS. The above results indicate that the CLTUS can be used to not only modulate the neural oscillation through the theta-phase-specific manipulation of the hippocampus but also effectively inhibit the seizure of a TLE mouse in time. CLTUS has large application potentials for the understanding of the causal relationship of neural circuits as well as for timely, effective, and non-invasive therapies of neurological diseases such as epilepsy and Parkinson’s disease.
format Online
Article
Text
id pubmed-7235408
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-72354082020-05-29 Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo Yang, Huifang Yuan, Yi Wang, Xingran Li, Xin Front Neurosci Neuroscience The closed-loop brain stimulation technique plays a key role in neural network information processing and therapies of neurological diseases. Transcranial ultrasound stimulation (TUS) is an established neuromodulation method for the neural oscillation in animals or human. All available TUS systems provide brain stimulation in an open-loop pattern. In this study, we developed a closed-loop transcranial ultrasound stimulation (CLTUS) system for real-time non-invasive neuromodulation in vivo. We used the CLTUS system to modulate the neural activities of the hippocampus of a wild-type mouse based on the phase of the theta rhythm recorded at the ultrasound-targeted location. In addition, we modulated the hippocampus of a temporal lobe epilepsy (TLE) mouse. The ultrasound stimulation increased the absolute power and reduced the relative power of the theta rhythm, which were independent of the specific phase of the theta rhythm. Compared with those of a sham stimulation, the latency of epileptic seizures was significantly increased, while the epileptic seizure duration was significantly decreased under the CLTUS. The above results indicate that the CLTUS can be used to not only modulate the neural oscillation through the theta-phase-specific manipulation of the hippocampus but also effectively inhibit the seizure of a TLE mouse in time. CLTUS has large application potentials for the understanding of the causal relationship of neural circuits as well as for timely, effective, and non-invasive therapies of neurological diseases such as epilepsy and Parkinson’s disease. Frontiers Media S.A. 2020-05-12 /pmc/articles/PMC7235408/ /pubmed/32477055 http://dx.doi.org/10.3389/fnins.2020.00445 Text en Copyright © 2020 Yang, Yuan, Wang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yang, Huifang
Yuan, Yi
Wang, Xingran
Li, Xin
Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title_full Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title_fullStr Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title_full_unstemmed Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title_short Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo
title_sort closed-loop transcranial ultrasound stimulation for real-time non-invasive neuromodulation in vivo
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235408/
https://www.ncbi.nlm.nih.gov/pubmed/32477055
http://dx.doi.org/10.3389/fnins.2020.00445
work_keys_str_mv AT yanghuifang closedlooptranscranialultrasoundstimulationforrealtimenoninvasiveneuromodulationinvivo
AT yuanyi closedlooptranscranialultrasoundstimulationforrealtimenoninvasiveneuromodulationinvivo
AT wangxingran closedlooptranscranialultrasoundstimulationforrealtimenoninvasiveneuromodulationinvivo
AT lixin closedlooptranscranialultrasoundstimulationforrealtimenoninvasiveneuromodulationinvivo