Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques

In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies. Linezolid (LZD) is a potent antibiotic for drug-resistant Gram-positive infections and is an effective treatment for TB. However, extended L...

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Detalles Bibliográficos
Autores principales: Winchell, Caylin G., Mishra, Bibhuti B., Phuah, Jia Yao, Saqib, Mohd, Nelson, Samantha J., Maiello, Pauline, Causgrove, Chelsea M., Ameel, Cassaundra L., Stein, Brianne, Borish, H. Jacob, White, Alexander G., Klein, Edwin C., Zimmerman, Matthew D., Dartois, Véronique, Lin, Philana Ling, Sassetti, Christopher M., Flynn, JoAnne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235418/
https://www.ncbi.nlm.nih.gov/pubmed/32477361
http://dx.doi.org/10.3389/fimmu.2020.00891

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