Is DPP4 inhibition a comrade or adversary in COVID-19 infection

Hypertension and Diabetes are the most common comorbid conditions in patients with COVID-19 and has been shown to adversely impact prognosis globally. It has been shown that hyperglycemia is one of the factors that increases the risk of poor outcomes in these patients. These patients are usually on multiple medications and recently a series of discussion on how Dipeptidyl peptidase 4 inhibitors (DPP4i) may be beneficial in these patients has been presented. This commentary presents a nuanced debate on why the DPP4i may not be beneficial in COVID-19 and that caution needs to be addressed in making any judgements until real world data is available.