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Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery

Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers for Disease Control and Preventi...

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Autores principales: Marquez, Lewis, Quave, Cassandra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235788/
https://www.ncbi.nlm.nih.gov/pubmed/32244276
http://dx.doi.org/10.3390/antibiotics9040150
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author Marquez, Lewis
Quave, Cassandra L.
author_facet Marquez, Lewis
Quave, Cassandra L.
author_sort Marquez, Lewis
collection PubMed
description Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers for Disease Control and Prevention’s (CDC) 2019 report, Antibiotic Resistance Threats in the United States. Conventional antifungals used to treat fungal infections are no longer as effective, leading to increased mortality. Compounding this issue, there are very few new antifungals currently in development. Plants from traditional medicine represent one possible research path to addressing the issue of MDR fungal pathogens. In this commentary piece, we discuss how medical ethnobotany—the study of how people use plants in medicine—can be used as a guide to identify plant species for the discovery and development of novel antifungal therapies.
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spelling pubmed-72357882020-05-22 Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery Marquez, Lewis Quave, Cassandra L. Antibiotics (Basel) Commentary Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of Candida auris and azole-resistant Aspergillus fumigatus were highlighted in the Centers for Disease Control and Prevention’s (CDC) 2019 report, Antibiotic Resistance Threats in the United States. Conventional antifungals used to treat fungal infections are no longer as effective, leading to increased mortality. Compounding this issue, there are very few new antifungals currently in development. Plants from traditional medicine represent one possible research path to addressing the issue of MDR fungal pathogens. In this commentary piece, we discuss how medical ethnobotany—the study of how people use plants in medicine—can be used as a guide to identify plant species for the discovery and development of novel antifungal therapies. MDPI 2020-03-31 /pmc/articles/PMC7235788/ /pubmed/32244276 http://dx.doi.org/10.3390/antibiotics9040150 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Marquez, Lewis
Quave, Cassandra L.
Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title_full Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title_fullStr Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title_full_unstemmed Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title_short Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery
title_sort prevalence and therapeutic challenges of fungal drug resistance: role for plants in drug discovery
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235788/
https://www.ncbi.nlm.nih.gov/pubmed/32244276
http://dx.doi.org/10.3390/antibiotics9040150
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