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Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respi...

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Autores principales: Kirichenko, Tatiana V., Sobenin, Igor A., Markina, Yuliya V., Gerasimova, Elena V., Grechko, Andrey V., Kashirskikh, Dmitry A., Romanenko, Elena B., Wu, Wei-Kai, Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235828/
https://www.ncbi.nlm.nih.gov/pubmed/32331341
http://dx.doi.org/10.3390/biology9040083
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author Kirichenko, Tatiana V.
Sobenin, Igor A.
Markina, Yuliya V.
Gerasimova, Elena V.
Grechko, Andrey V.
Kashirskikh, Dmitry A.
Romanenko, Elena B.
Wu, Wei-Kai
Orekhov, Alexander N.
author_facet Kirichenko, Tatiana V.
Sobenin, Igor A.
Markina, Yuliya V.
Gerasimova, Elena V.
Grechko, Andrey V.
Kashirskikh, Dmitry A.
Romanenko, Elena B.
Wu, Wei-Kai
Orekhov, Alexander N.
author_sort Kirichenko, Tatiana V.
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respiratory function, and exacerbation frequency in 60 patients with moderate severity of COPD. Inflaminat is a combination of natural ingredients black elder (Sambucus nigra L.) berries, violet (Viola tricolor L.) herb, and calendula (Calendula officinalis L.) flowers. The preparation has been previously demonstrated to possess anticytokine and anti-inflammatory effects in experimental studies. In present study, COPD dynamics were evaluated by means of BCSS (Breathlessness, Cough, and Sputum Scale) and spirometry tests. It was shown that 6-months Inflaminat administration led to significant decrease of BCSS points from 3.0 ± 0.6 to 1.9 ± 0.7, (p = 0.002) as well as significant increase of FEV1 from 66 ± 18% to 73 ± 17%, (p = 0.042); there were no beneficial dynamics in placebo group. Side effects associated with preparation administration were not identified. The results of the study suggest that Inflaminat may be employed in treatment of patients with moderate severity of COPD, since it has a positive effect on COPD symptoms according BCSS and indicators of respiratory function FEV1.
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spelling pubmed-72358282020-05-22 Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study Kirichenko, Tatiana V. Sobenin, Igor A. Markina, Yuliya V. Gerasimova, Elena V. Grechko, Andrey V. Kashirskikh, Dmitry A. Romanenko, Elena B. Wu, Wei-Kai Orekhov, Alexander N. Biology (Basel) Article Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respiratory function, and exacerbation frequency in 60 patients with moderate severity of COPD. Inflaminat is a combination of natural ingredients black elder (Sambucus nigra L.) berries, violet (Viola tricolor L.) herb, and calendula (Calendula officinalis L.) flowers. The preparation has been previously demonstrated to possess anticytokine and anti-inflammatory effects in experimental studies. In present study, COPD dynamics were evaluated by means of BCSS (Breathlessness, Cough, and Sputum Scale) and spirometry tests. It was shown that 6-months Inflaminat administration led to significant decrease of BCSS points from 3.0 ± 0.6 to 1.9 ± 0.7, (p = 0.002) as well as significant increase of FEV1 from 66 ± 18% to 73 ± 17%, (p = 0.042); there were no beneficial dynamics in placebo group. Side effects associated with preparation administration were not identified. The results of the study suggest that Inflaminat may be employed in treatment of patients with moderate severity of COPD, since it has a positive effect on COPD symptoms according BCSS and indicators of respiratory function FEV1. MDPI 2020-04-22 /pmc/articles/PMC7235828/ /pubmed/32331341 http://dx.doi.org/10.3390/biology9040083 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kirichenko, Tatiana V.
Sobenin, Igor A.
Markina, Yuliya V.
Gerasimova, Elena V.
Grechko, Andrey V.
Kashirskikh, Dmitry A.
Romanenko, Elena B.
Wu, Wei-Kai
Orekhov, Alexander N.
Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title_full Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title_fullStr Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title_full_unstemmed Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title_short Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study
title_sort clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235828/
https://www.ncbi.nlm.nih.gov/pubmed/32331341
http://dx.doi.org/10.3390/biology9040083
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