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Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrume...

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Autores principales: Castaldo, Alice, Iacotucci, Paola, Carnovale, Vincenzo, Cimino, Roberta, Liguori, Renato, Comegna, Marika, Raia, Valeria, Corso, Gaetano, Castaldo, Giuseppe, Gelzo, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235910/
https://www.ncbi.nlm.nih.gov/pubmed/32326546
http://dx.doi.org/10.3390/diagnostics10040222
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author Castaldo, Alice
Iacotucci, Paola
Carnovale, Vincenzo
Cimino, Roberta
Liguori, Renato
Comegna, Marika
Raia, Valeria
Corso, Gaetano
Castaldo, Giuseppe
Gelzo, Monica
author_facet Castaldo, Alice
Iacotucci, Paola
Carnovale, Vincenzo
Cimino, Roberta
Liguori, Renato
Comegna, Marika
Raia, Valeria
Corso, Gaetano
Castaldo, Giuseppe
Gelzo, Monica
author_sort Castaldo, Alice
collection PubMed
description About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and Pseudomonas aeruginosa or Stenotrophomonas maltophilia colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels.
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spelling pubmed-72359102020-05-28 Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis Castaldo, Alice Iacotucci, Paola Carnovale, Vincenzo Cimino, Roberta Liguori, Renato Comegna, Marika Raia, Valeria Corso, Gaetano Castaldo, Giuseppe Gelzo, Monica Diagnostics (Basel) Article About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and Pseudomonas aeruginosa or Stenotrophomonas maltophilia colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels. MDPI 2020-04-15 /pmc/articles/PMC7235910/ /pubmed/32326546 http://dx.doi.org/10.3390/diagnostics10040222 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castaldo, Alice
Iacotucci, Paola
Carnovale, Vincenzo
Cimino, Roberta
Liguori, Renato
Comegna, Marika
Raia, Valeria
Corso, Gaetano
Castaldo, Giuseppe
Gelzo, Monica
Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title_full Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title_fullStr Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title_full_unstemmed Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title_short Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis
title_sort salivary cytokines and airways disease severity in patients with cystic fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235910/
https://www.ncbi.nlm.nih.gov/pubmed/32326546
http://dx.doi.org/10.3390/diagnostics10040222
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