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Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions

Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining...

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Autores principales: Nowak, Karolina, Jurek, Tomasz, Zawadzki, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235919/
https://www.ncbi.nlm.nih.gov/pubmed/32325891
http://dx.doi.org/10.3390/diagnostics10040236
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author Nowak, Karolina
Jurek, Tomasz
Zawadzki, Marcin
author_facet Nowak, Karolina
Jurek, Tomasz
Zawadzki, Marcin
author_sort Nowak, Karolina
collection PubMed
description Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining glucose, lactate, acetone, β-hydroxybutyric acid (BHB), and 1,5-anhydroglucitol (1,5-AG) in postmortem blood/serum, urine, and vitreous humor (VH). Biological material was collected during autopsies. The study group consisted of 50 diabetics, while the control group consisted of 50 non-diabetics, who died a sudden death, with negative test results for the presence of ethyl alcohol and were not resuscitated before death. Statistical analysis was performed using the IBM SPSS Statistics 25 software package. The most statistically significant difference between the two groups was observed for mean 1,5-AG concentration. The authors found many correlations between the concentration of the examined markers in different materials, mainly between blood/serum and VH. The most suitable short-term glycemic marker in postmortem diagnosis is 1,5-AG. Diagnosis may be supported with determinations of acetone and BHB. For medicolegal assessment, the interpretation of the biochemical test results should comprise information on circumstances of death, medical history, results of other toxicological and histopathological tests, and autopsy report.
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spelling pubmed-72359192020-05-28 Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions Nowak, Karolina Jurek, Tomasz Zawadzki, Marcin Diagnostics (Basel) Article Diabetes mellitus is classified as the epidemic of the 21st century. Due to the fact that acute carbohydrate metabolism disorders usually do not indicate morphological change, postmortem diagnosis is required to perform biochemical tests. The authors decided to evaluate the usefulness of determining glucose, lactate, acetone, β-hydroxybutyric acid (BHB), and 1,5-anhydroglucitol (1,5-AG) in postmortem blood/serum, urine, and vitreous humor (VH). Biological material was collected during autopsies. The study group consisted of 50 diabetics, while the control group consisted of 50 non-diabetics, who died a sudden death, with negative test results for the presence of ethyl alcohol and were not resuscitated before death. Statistical analysis was performed using the IBM SPSS Statistics 25 software package. The most statistically significant difference between the two groups was observed for mean 1,5-AG concentration. The authors found many correlations between the concentration of the examined markers in different materials, mainly between blood/serum and VH. The most suitable short-term glycemic marker in postmortem diagnosis is 1,5-AG. Diagnosis may be supported with determinations of acetone and BHB. For medicolegal assessment, the interpretation of the biochemical test results should comprise information on circumstances of death, medical history, results of other toxicological and histopathological tests, and autopsy report. MDPI 2020-04-19 /pmc/articles/PMC7235919/ /pubmed/32325891 http://dx.doi.org/10.3390/diagnostics10040236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nowak, Karolina
Jurek, Tomasz
Zawadzki, Marcin
Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title_full Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title_fullStr Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title_full_unstemmed Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title_short Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions
title_sort postmortem determination of short-term markers of hyperglycemia for the purposes of medicolegal opinions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235919/
https://www.ncbi.nlm.nih.gov/pubmed/32325891
http://dx.doi.org/10.3390/diagnostics10040236
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