Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †

Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic sw...

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Detalles Bibliográficos
Autores principales: Anwar, Areeba, Siddiqui, Ruqaiyyah, Khan, Naveed Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Concept Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235994/
https://www.ncbi.nlm.nih.gov/pubmed/32316619
http://dx.doi.org/10.3390/biology9040079
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author Anwar, Areeba
Siddiqui, Ruqaiyyah
Khan, Naveed Ahmed
author_facet Anwar, Areeba
Siddiqui, Ruqaiyyah
Khan, Naveed Ahmed
author_sort Anwar, Areeba
collection PubMed
description Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, Acanthamoeba castellanii, as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation.
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spelling pubmed-72359942020-05-28 Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation † Anwar, Areeba Siddiqui, Ruqaiyyah Khan, Naveed Ahmed Biology (Basel) Concept Paper Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, Acanthamoeba castellanii, as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation. MDPI 2020-04-17 /pmc/articles/PMC7235994/ /pubmed/32316619 http://dx.doi.org/10.3390/biology9040079 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Concept Paper
Anwar, Areeba
Siddiqui, Ruqaiyyah
Khan, Naveed Ahmed
Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title_full Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title_fullStr Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title_full_unstemmed Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title_short Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation †
title_sort whole organism model to study molecular mechanisms of differentiation and dedifferentiation †
topic Concept Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235994/
https://www.ncbi.nlm.nih.gov/pubmed/32316619
http://dx.doi.org/10.3390/biology9040079
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AT khannaveedahmed wholeorganismmodeltostudymolecularmechanismsofdifferentiationanddedifferentiation

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