Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies

[Image: see text] An agonist–antagonist switching strategy was performed to discover novel PPARα antagonists. Phenyldiazenyl derivatives of fibrates were developed, bearing sulfonimide or amide functional groups. A second series of compounds was synthesized, replacing the phenyldiazenyl moiety with...

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Detalles Bibliográficos
Autores principales: Ammazzalorso, Alessandra, Bruno, Isabella, Florio, Rosalba, De Lellis, Laura, Laghezza, Antonio, Cerchia, Carmen, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Tortorella, Paolo, Veschi, Serena, Loiodice, Fulvio, Lavecchia, Antonio, Cama, Alessandro, Amoroso, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236056/
https://www.ncbi.nlm.nih.gov/pubmed/32435362
http://dx.doi.org/10.1021/acsmedchemlett.9b00666

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