p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation

BACKGROUND: Most nanoparticles (NPs) reportedly block autophagic flux, thereby upregulating p62/SQSTM1 through degradation inhibition. p62 also acts as a multifunctional scaffold protein with multiple domains, and is involved in various cellular processes. However, the autophagy substrate-independen...

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Detalles Bibliográficos
Autores principales: Wu, Yifan, Jin, Yang, Sun, Tianyu, Zhu, Piaoyu, Li, Jinlong, Zhang, Qinglin, Wang, Xiaoke, Jiang, Junkang, Chen, Gang, Zhao, Xinyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236097/
https://www.ncbi.nlm.nih.gov/pubmed/32429946
http://dx.doi.org/10.1186/s12951-020-00634-1

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