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RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

BACKGROUND: N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6A demethylase ALKBH5 in pancreatic cancer (PC). METHODS: The expression of ALKBH5 and its clinic...

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Detalles Bibliográficos
Autores principales:	Guo, Xingya, Li, Kai, Jiang, Weiliang, Hu, Yangyang, Xiao, Wenqin, Huang, Yinshi, Feng, Yun, Pan, Qin, Wan, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236181/ https://www.ncbi.nlm.nih.gov/pubmed/32429928 http://dx.doi.org/10.1186/s12943-020-01158-w

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