Cargando…

Gene modification strategies for next-generation CAR T cells against solid cancers

Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies. However, CAR T therapy against solid tumors is less effective. Antigen targeting; an immunosuppressive tum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Yonggui, Li, Yilu, Shao, Yupei, Zhang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236186/ https://www.ncbi.nlm.nih.gov/pubmed/32423475 http://dx.doi.org/10.1186/s13045-020-00890-6

Ejemplares similares

CAR models: next-generation CAR modifications for enhanced T-cell function
por: Abate-Daga, Daniel, et al.
Publicado: (2016)

Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors
por: Yu, Tao, et al.
Publicado: (2022)

Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors
por: DeRenzo, Christopher, et al.
Publicado: (2019)

Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers
por: Kyte, Jon Amund
Publicado: (2022)

Engineering the next generation of CAR-NK immunotherapies
por: Biederstädt, Alexander, et al.
Publicado: (2021)

Adaptor CAR Platforms—Next Generation of T Cell-Based Cancer Immunotherapy
por: Arndt, Claudia, et al.
Publicado: (2020)

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
por: Dimitri, Alexander, et al.
Publicado: (2022)

S79. CAR strategies in solid tumours
por: Rossig, C
Publicado: (2014)

Remote controlling of CAR-T cells and toxicity management: Molecular switches and next generation CARs
por: Moghanloo, Ehsan, et al.
Publicado: (2021)

Targeting NR4As, a new strategy to fine-tune CAR-T cells against solid tumors
por: Li, Feng, et al.
Publicado: (2019)

CAR-T: What Is Next?
por: Chen, Yi-Ju, et al.
Publicado: (2023)

Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma
por: Petersen, Christopher T., et al.
Publicado: (2019)

Engineering Next-Generation CAR-T Cells for Better Toxicity Management
por: Andrea, Alain E., et al.
Publicado: (2020)

Next generations of CAR-T cells - new therapeutic opportunities in hematology?
por: Tomasik, Jaromir, et al.
Publicado: (2022)

New Strategies for the Treatment of Solid Tumors with CAR-T Cells
por: Zhang, Hao, et al.
Publicado: (2016)

Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells
por: Morgan, Michael A., et al.
Publicado: (2020)

Teaching an old dog new tricks: next-generation CAR T cells
por: Tokarew, Nicholas, et al.
Publicado: (2018)

Next Generation CD44v6-Specific CAR-NK Cells Effective against Triple Negative Breast Cancer
por: Raftery, Martin J., et al.
Publicado: (2023)

The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors
por: Hadiloo, Kaveh, et al.
Publicado: (2023)

Obstacles and Coping Strategies of CAR-T Cell Immunotherapy in Solid Tumors
por: Miao, Lele, et al.
Publicado: (2021)

Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR
por: Zhang, Angela Q., et al.
Publicado: (2023)

A long way to the battlefront: CAR T cell therapy against solid cancers
por: Wang, Zhicai, et al.
Publicado: (2019)

Engineering CAR-T Cells for Improved Function Against Solid Tumors
por: Morgan, Michael A., et al.
Publicado: (2018)

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
por: Ghahri-Saremi, Navid, et al.
Publicado: (2021)

Switchable CAR T cell strategy against osteosarcoma
por: Hidalgo, Laura, et al.
Publicado: (2023)

Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells
por: Wang, Zhixiong, et al.
Publicado: (2020)

Next frontiers in CAR T-cell therapy
por: Brown, Christine E, et al.
Publicado: (2016)

Generation and Functional Characterization of PLAP CAR-T Cells against Cervical Cancer Cells
por: Yekehfallah, Vahid, et al.
Publicado: (2022)

Armored CAR T-Cells: The Next Chapter in T-Cell Cancer Immunotherapy
por: Hawkins, Elizabeth R, et al.
Publicado: (2021)

Next generation sequencing‐based gene panel tests for the management of solid tumors
por: Nagahashi, Masayuki, et al.
Publicado: (2018)

Evaluation of CAR-T Cells’ Cytotoxicity against Modified Solid Tumor Cell Lines
por: Valiullina, Aigul Kh., et al.
Publicado: (2023)

CAR-T with License to Kill Solid Tumors in Search of a Winning Strategy
por: Sacchetti, Benedetto, et al.
Publicado: (2019)

CAR‐NK cells: the next wave of cellular therapy for cancer
por: Daher, May, et al.
Publicado: (2021)

CAR-T cell combination therapy: the next revolution in cancer treatment
por: Al-Haideri, Maysoon, et al.
Publicado: (2022)

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
por: Rossig, Claudia, et al.
Publicado: (2018)

Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
por: Patel, Shabnum, et al.
Publicado: (2019)

Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
por: Goodman, Daniel B., et al.
Publicado: (2022)

Next generation sequencing: clinical applications in solid tumours
por: Müllauer, Leonhard
Publicado: (2017)

Binding and Efficacy of Anti-Robo4 CAR-T Cells against Solid Tumors
por: Hirobe, Sachiko, et al.
Publicado: (2022)

Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance
por: Qin, Yue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tv76obtr2cq27gggsc9ikf65gq