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Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study

BACKGROUND: Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmonary dysplasia. Surfactant, however, can be inactivated by bacterial infection....

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Autores principales: Maiwald, Christian A., Dick, Julia, Marschal, Matthias, Gille, Christian, Franz, Axel R., Poets, Christian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236511/
https://www.ncbi.nlm.nih.gov/pubmed/32429874
http://dx.doi.org/10.1186/s12887-020-02147-0
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author Maiwald, Christian A.
Dick, Julia
Marschal, Matthias
Gille, Christian
Franz, Axel R.
Poets, Christian F.
author_facet Maiwald, Christian A.
Dick, Julia
Marschal, Matthias
Gille, Christian
Franz, Axel R.
Poets, Christian F.
author_sort Maiwald, Christian A.
collection PubMed
description BACKGROUND: Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmonary dysplasia. Surfactant, however, can be inactivated by bacterial infection. Therefore, potential routes of microbe transmission into the airway are of interest. The aim of this study was to evaluate microbiological contamination of catheters used for LISA procedures and its association with postnatal age. METHODS: Catheter tips used for LISA procedures via the nasal route (LISA-n) in infants with RDS were placed into a sterile eSwab container directly after the procedure, cultured and examined for microbiological contamination. RESULTS: Interpretable results could be collected from 20 catheter tips. Four showed positive culture results (20%) with microbes potentially associated with the development of early onset neonatal sepsis. Risk of positive microbe detection increased with postnatal age (< 4 h: 10%; 4–18 h: 20%; > 18 h: 40%). CONCLUSIONS: In this pilot study, the risk of tracheal microbe transmission following the LISA-n procedure increased with postnatal age. Although the clinical relevance of this finding is unclear, earlier surfactant administration might reduce the risk of catheter contamination. TRIAL REGISTRATION NUMBER: Substudy of the registered Trial: feasibility study – Neofact: NCT04086095, www.ClinicalTrials.gov, September 11, 2019.
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spelling pubmed-72365112020-05-29 Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study Maiwald, Christian A. Dick, Julia Marschal, Matthias Gille, Christian Franz, Axel R. Poets, Christian F. BMC Pediatr Research Article BACKGROUND: Respiratory distress syndrome (RDS) is a frequent complication of premature birth. Treating RDS by continuous positive airway pressure and less invasive surfactant administration (LISA) may reduce bronchopulmonary dysplasia. Surfactant, however, can be inactivated by bacterial infection. Therefore, potential routes of microbe transmission into the airway are of interest. The aim of this study was to evaluate microbiological contamination of catheters used for LISA procedures and its association with postnatal age. METHODS: Catheter tips used for LISA procedures via the nasal route (LISA-n) in infants with RDS were placed into a sterile eSwab container directly after the procedure, cultured and examined for microbiological contamination. RESULTS: Interpretable results could be collected from 20 catheter tips. Four showed positive culture results (20%) with microbes potentially associated with the development of early onset neonatal sepsis. Risk of positive microbe detection increased with postnatal age (< 4 h: 10%; 4–18 h: 20%; > 18 h: 40%). CONCLUSIONS: In this pilot study, the risk of tracheal microbe transmission following the LISA-n procedure increased with postnatal age. Although the clinical relevance of this finding is unclear, earlier surfactant administration might reduce the risk of catheter contamination. TRIAL REGISTRATION NUMBER: Substudy of the registered Trial: feasibility study – Neofact: NCT04086095, www.ClinicalTrials.gov, September 11, 2019. BioMed Central 2020-05-19 /pmc/articles/PMC7236511/ /pubmed/32429874 http://dx.doi.org/10.1186/s12887-020-02147-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Maiwald, Christian A.
Dick, Julia
Marschal, Matthias
Gille, Christian
Franz, Axel R.
Poets, Christian F.
Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title_full Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title_fullStr Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title_full_unstemmed Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title_short Microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
title_sort microbiological analyses of nasally guided catheters after less invasive surfactant administration – a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236511/
https://www.ncbi.nlm.nih.gov/pubmed/32429874
http://dx.doi.org/10.1186/s12887-020-02147-0
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