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author Ainslie, Kylie E. C.
Walters, Caroline E.
Fu, Han
Bhatia, Sangeeta
Wang, Haowei
Xi, Xiaoyue
Baguelin, Marc
Bhatt, Samir
Boonyasiri, Adhiratha
Boyd, Olivia
Cattarino, Lorenzo
Ciavarella, Constanze
Cucunuba, Zulma
Cuomo-Dannenburg, Gina
Dighe, Amy
Dorigatti, Ilaria
van Elsland, Sabine L
FitzJohn, Rich
Gaythorpe, Katy
Ghani, Azra C
Green, Will
Hamlet, Arran
Hinsley, Wes
Imai, Natsuko
Jorgensen, David
Knock, Edward
Laydon, Daniel
Nedjati-Gilani, Gemma
Okell, Lucy C
Siveroni, Igor
Thompson, Hayley A
Unwin, H. Juliette T.
Verity, Robert
Vollmer, Michaela
Walker, Patrick G T
Wang, Yuanrong
Watson, Oliver J
Whittaker, Charles
Winskill, Peter
Donnelly, Christl A
Ferguson, Neil M
Riley, Steven
author_facet Ainslie, Kylie E. C.
Walters, Caroline E.
Fu, Han
Bhatia, Sangeeta
Wang, Haowei
Xi, Xiaoyue
Baguelin, Marc
Bhatt, Samir
Boonyasiri, Adhiratha
Boyd, Olivia
Cattarino, Lorenzo
Ciavarella, Constanze
Cucunuba, Zulma
Cuomo-Dannenburg, Gina
Dighe, Amy
Dorigatti, Ilaria
van Elsland, Sabine L
FitzJohn, Rich
Gaythorpe, Katy
Ghani, Azra C
Green, Will
Hamlet, Arran
Hinsley, Wes
Imai, Natsuko
Jorgensen, David
Knock, Edward
Laydon, Daniel
Nedjati-Gilani, Gemma
Okell, Lucy C
Siveroni, Igor
Thompson, Hayley A
Unwin, H. Juliette T.
Verity, Robert
Vollmer, Michaela
Walker, Patrick G T
Wang, Yuanrong
Watson, Oliver J
Whittaker, Charles
Winskill, Peter
Donnelly, Christl A
Ferguson, Neil M
Riley, Steven
author_sort Ainslie, Kylie E. C.
collection PubMed
description Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city of Wuhan, Hubei, China imposed strict social distancing in Wuhan on 23 January 2020 followed closely by similar measures in other provinces. These interventions have impacted economic productivity in China, and the ability of the Chinese economy to resume without restarting the epidemic was not clear. Methods: Using daily reported cases from mainland China and Hong Kong SAR, we estimated transmissibility over time and compared it to daily within-city movement, as a proxy for economic activity. Results: Initially, within-city movement and transmission were very strongly correlated in the five mainland provinces most affected by the epidemic and Beijing. However, that correlation decreased rapidly after the initial sharp fall in transmissibility. In general, towards the end of the study period, the correlation was no longer apparent, despite substantial increases in within-city movement. A similar analysis for Hong Kong shows that intermediate levels of local activity were maintained while avoiding a large outbreak. At the very end of the study period, when China began to experience the re-introduction of a small number of cases from Europe and the United States, there is an apparent up-tick in transmission. Conclusions: Although these results do not preclude future substantial increases in incidence, they suggest that after very intense social distancing (which resulted in containment), China successfully exited its lockdown to some degree. Elsewhere, movement data are being used as proxies for economic activity to assess the impact of interventions. The results presented here illustrate how the eventual decorrelation between transmission and movement is likely a key feature of successful COVID-19 exit strategies.
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spelling pubmed-72365872020-06-03 Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment Ainslie, Kylie E. C. Walters, Caroline E. Fu, Han Bhatia, Sangeeta Wang, Haowei Xi, Xiaoyue Baguelin, Marc Bhatt, Samir Boonyasiri, Adhiratha Boyd, Olivia Cattarino, Lorenzo Ciavarella, Constanze Cucunuba, Zulma Cuomo-Dannenburg, Gina Dighe, Amy Dorigatti, Ilaria van Elsland, Sabine L FitzJohn, Rich Gaythorpe, Katy Ghani, Azra C Green, Will Hamlet, Arran Hinsley, Wes Imai, Natsuko Jorgensen, David Knock, Edward Laydon, Daniel Nedjati-Gilani, Gemma Okell, Lucy C Siveroni, Igor Thompson, Hayley A Unwin, H. Juliette T. Verity, Robert Vollmer, Michaela Walker, Patrick G T Wang, Yuanrong Watson, Oliver J Whittaker, Charles Winskill, Peter Donnelly, Christl A Ferguson, Neil M Riley, Steven Wellcome Open Res Research Article Background: The COVID-19 epidemic was declared a Global Pandemic by WHO on 11 March 2020. By 24 March 2020, over 440,000 cases and almost 20,000 deaths had been reported worldwide. In response to the fast-growing epidemic, which began in the Chinese city of Wuhan, Hubei, China imposed strict social distancing in Wuhan on 23 January 2020 followed closely by similar measures in other provinces. These interventions have impacted economic productivity in China, and the ability of the Chinese economy to resume without restarting the epidemic was not clear. Methods: Using daily reported cases from mainland China and Hong Kong SAR, we estimated transmissibility over time and compared it to daily within-city movement, as a proxy for economic activity. Results: Initially, within-city movement and transmission were very strongly correlated in the five mainland provinces most affected by the epidemic and Beijing. However, that correlation decreased rapidly after the initial sharp fall in transmissibility. In general, towards the end of the study period, the correlation was no longer apparent, despite substantial increases in within-city movement. A similar analysis for Hong Kong shows that intermediate levels of local activity were maintained while avoiding a large outbreak. At the very end of the study period, when China began to experience the re-introduction of a small number of cases from Europe and the United States, there is an apparent up-tick in transmission. Conclusions: Although these results do not preclude future substantial increases in incidence, they suggest that after very intense social distancing (which resulted in containment), China successfully exited its lockdown to some degree. Elsewhere, movement data are being used as proxies for economic activity to assess the impact of interventions. The results presented here illustrate how the eventual decorrelation between transmission and movement is likely a key feature of successful COVID-19 exit strategies. F1000 Research Limited 2020-10-01 /pmc/articles/PMC7236587/ /pubmed/32500100 http://dx.doi.org/10.12688/wellcomeopenres.15843.2 Text en Copyright: © 2020 Ainslie KEC et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ainslie, Kylie E. C.
Walters, Caroline E.
Fu, Han
Bhatia, Sangeeta
Wang, Haowei
Xi, Xiaoyue
Baguelin, Marc
Bhatt, Samir
Boonyasiri, Adhiratha
Boyd, Olivia
Cattarino, Lorenzo
Ciavarella, Constanze
Cucunuba, Zulma
Cuomo-Dannenburg, Gina
Dighe, Amy
Dorigatti, Ilaria
van Elsland, Sabine L
FitzJohn, Rich
Gaythorpe, Katy
Ghani, Azra C
Green, Will
Hamlet, Arran
Hinsley, Wes
Imai, Natsuko
Jorgensen, David
Knock, Edward
Laydon, Daniel
Nedjati-Gilani, Gemma
Okell, Lucy C
Siveroni, Igor
Thompson, Hayley A
Unwin, H. Juliette T.
Verity, Robert
Vollmer, Michaela
Walker, Patrick G T
Wang, Yuanrong
Watson, Oliver J
Whittaker, Charles
Winskill, Peter
Donnelly, Christl A
Ferguson, Neil M
Riley, Steven
Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title_full Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title_fullStr Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title_full_unstemmed Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title_short Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment
title_sort evidence of initial success for china exiting covid-19 social distancing policy after achieving containment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236587/
https://www.ncbi.nlm.nih.gov/pubmed/32500100
http://dx.doi.org/10.12688/wellcomeopenres.15843.2
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