Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.

Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with incre...

Descripción completa

Detalles Bibliográficos
Autores principales: Creed, Marina A., Ballesteros, Enrique, Jr, L. John Greenfield, Imitola, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236713/
https://www.ncbi.nlm.nih.gov/pubmed/32554285
http://dx.doi.org/10.1016/j.msard.2020.102199
_version_ 1783536199548272640
author Creed, Marina A.
Ballesteros, Enrique
Jr, L. John Greenfield
Imitola, Jaime
author_facet Creed, Marina A.
Ballesteros, Enrique
Jr, L. John Greenfield
Imitola, Jaime
author_sort Creed, Marina A.
collection PubMed
description Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection.
format Online
Article
Text
id pubmed-7236713
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-72367132020-05-19 Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder. Creed, Marina A. Ballesteros, Enrique Jr, L. John Greenfield Imitola, Jaime Mult Scler Relat Disord Case Report Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection. Elsevier B.V. 2020-09 2020-05-19 /pmc/articles/PMC7236713/ /pubmed/32554285 http://dx.doi.org/10.1016/j.msard.2020.102199 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Creed, Marina A.
Ballesteros, Enrique
Jr, L. John Greenfield
Imitola, Jaime
Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title_full Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title_fullStr Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title_full_unstemmed Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title_short Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
title_sort mild covid-19 infection despite chronic b cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236713/
https://www.ncbi.nlm.nih.gov/pubmed/32554285
http://dx.doi.org/10.1016/j.msard.2020.102199
work_keys_str_mv AT creedmarinaa mildcovid19infectiondespitechronicbcelldepletioninapatientwithaquaporin4positiveneuromyelitisopticaspectrumdisorder
AT ballesterosenrique mildcovid19infectiondespitechronicbcelldepletioninapatientwithaquaporin4positiveneuromyelitisopticaspectrumdisorder
AT jrljohngreenfield mildcovid19infectiondespitechronicbcelldepletioninapatientwithaquaporin4positiveneuromyelitisopticaspectrumdisorder
AT imitolajaime mildcovid19infectiondespitechronicbcelldepletioninapatientwithaquaporin4positiveneuromyelitisopticaspectrumdisorder

Ejemplares similares