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Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

INTRODUCTION: Current drug dosing in preterm infants is standardized, mostly based on bodyweight. Still, covariates such as gestational and postnatal age may importantly alter pharmacokinetics and pharmacodynamics. Evaluation of drug therapy in these patients is very difficult because objective phar...

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Detalles Bibliográficos
Autores principales:	Poppe, Jarinda A., van Weteringen, Willem, Sebek, Lotte L. G., Knibbe, Catherijne A. J., Reiss, Irwin K. M., Simons, Sinno H. P., Flint, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236770/ https://www.ncbi.nlm.nih.gov/pubmed/32477133 http://dx.doi.org/10.3389/fphar.2020.00665

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