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Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

BACKGROUND: Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibi...

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Detalles Bibliográficos
Autores principales:	Lernoux, Manon, Schnekenburger, Michael, Losson, Hélène, Vermeulen, Koen, Hahn, Hyunggu, Gérard, Déborah, Lee, Jin-Young, Mazumder, Aloran, Ahamed, Muneer, Christov, Christo, Kim, Dong-Wook, Dicato, Mario, Bormans, Guy, Han, Byung Woo, Diederich, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236970/ https://www.ncbi.nlm.nih.gov/pubmed/32430012 http://dx.doi.org/10.1186/s13148-020-00839-z

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