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Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation

During eukaryotic DNA replication, DNA polymerase alpha/primase (Pol α) initiates synthesis on both the leading and lagging strands. It is unknown whether leading- and lagging-strand priming are mechanistically identical, and whether Pol α associates processively or distributively with the replisome...

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Detalles Bibliográficos
Autores principales:	Porcella, Sarina Y., Koussa, Natasha C., Tang, Colin P., Kramer, Daphne N., Srivastava, Priyanka, Smith, Duncan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237047/ https://www.ncbi.nlm.nih.gov/pubmed/32379761 http://dx.doi.org/10.1371/journal.pgen.1008755

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