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Hydrogels in the clinic

Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer...

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Detalles Bibliográficos
Autores principales: Mandal, Abhirup, Clegg, John R., Anselmo, Aaron C., Mitragotri, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237140/
https://www.ncbi.nlm.nih.gov/pubmed/32440563
http://dx.doi.org/10.1002/btm2.10158
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author Mandal, Abhirup
Clegg, John R.
Anselmo, Aaron C.
Mitragotri, Samir
author_facet Mandal, Abhirup
Clegg, John R.
Anselmo, Aaron C.
Mitragotri, Samir
author_sort Mandal, Abhirup
collection PubMed
description Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation.
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spelling pubmed-72371402020-05-21 Hydrogels in the clinic Mandal, Abhirup Clegg, John R. Anselmo, Aaron C. Mitragotri, Samir Bioeng Transl Med Reviews Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation. John Wiley & Sons, Inc. 2020-04-03 /pmc/articles/PMC7237140/ /pubmed/32440563 http://dx.doi.org/10.1002/btm2.10158 Text en © 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Mandal, Abhirup
Clegg, John R.
Anselmo, Aaron C.
Mitragotri, Samir
Hydrogels in the clinic
title Hydrogels in the clinic
title_full Hydrogels in the clinic
title_fullStr Hydrogels in the clinic
title_full_unstemmed Hydrogels in the clinic
title_short Hydrogels in the clinic
title_sort hydrogels in the clinic
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237140/
https://www.ncbi.nlm.nih.gov/pubmed/32440563
http://dx.doi.org/10.1002/btm2.10158
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