A self‐adhesive microneedle patch with drug loading capability through swelling effect

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a...

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Autores principales: Chew, Sharon W. T., Shah, Ankur H., Zheng, Mengjia, Chang, Hao, Wiraja, Christian, Steele, Terry W. J., Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237146/
https://www.ncbi.nlm.nih.gov/pubmed/32440562
http://dx.doi.org/10.1002/btm2.10157
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author Chew, Sharon W. T.
Shah, Ankur H.
Zheng, Mengjia
Chang, Hao
Wiraja, Christian
Steele, Terry W. J.
Xu, Chenjie
author_facet Chew, Sharon W. T.
Shah, Ankur H.
Zheng, Mengjia
Chang, Hao
Wiraja, Christian
Steele, Terry W. J.
Xu, Chenjie
author_sort Chew, Sharon W. T.
collection PubMed
description Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post‐fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm(−2). Additional post‐fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.
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spelling pubmed-72371462020-05-21 A self‐adhesive microneedle patch with drug loading capability through swelling effect Chew, Sharon W. T. Shah, Ankur H. Zheng, Mengjia Chang, Hao Wiraja, Christian Steele, Terry W. J. Xu, Chenjie Bioeng Transl Med Research Reports Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug‐loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post‐fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm(−2). Additional post‐fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies. John Wiley & Sons, Inc. 2020-02-29 /pmc/articles/PMC7237146/ /pubmed/32440562 http://dx.doi.org/10.1002/btm2.10157 Text en © 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Reports
Chew, Sharon W. T.
Shah, Ankur H.
Zheng, Mengjia
Chang, Hao
Wiraja, Christian
Steele, Terry W. J.
Xu, Chenjie
A self‐adhesive microneedle patch with drug loading capability through swelling effect
title A self‐adhesive microneedle patch with drug loading capability through swelling effect
title_full A self‐adhesive microneedle patch with drug loading capability through swelling effect
title_fullStr A self‐adhesive microneedle patch with drug loading capability through swelling effect
title_full_unstemmed A self‐adhesive microneedle patch with drug loading capability through swelling effect
title_short A self‐adhesive microneedle patch with drug loading capability through swelling effect
title_sort self‐adhesive microneedle patch with drug loading capability through swelling effect
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237146/
https://www.ncbi.nlm.nih.gov/pubmed/32440562
http://dx.doi.org/10.1002/btm2.10157
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