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Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays
Porphyrins, with or without metal ions (MPs), have been explored and applied in optical and electrochemical sensor fields owing to their special physicochemical properties. The presence of four nitrogen atoms at the centers of porphyrins means that porphyrins chelate most metal ions, which changes t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237200/ https://www.ncbi.nlm.nih.gov/pubmed/32478033 http://dx.doi.org/10.3389/fchem.2020.00362 |
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author | Wang, Hui Ramnani, Pankaj Pham, Tung Villarreal, Claudia Chaves Yu, Xuejun Liu, Gang Mulchandani, Ashok |
author_facet | Wang, Hui Ramnani, Pankaj Pham, Tung Villarreal, Claudia Chaves Yu, Xuejun Liu, Gang Mulchandani, Ashok |
author_sort | Wang, Hui |
collection | PubMed |
description | Porphyrins, with or without metal ions (MPs), have been explored and applied in optical and electrochemical sensor fields owing to their special physicochemical properties. The presence of four nitrogen atoms at the centers of porphyrins means that porphyrins chelate most metal ions, which changes the binding ability of MPs with gas molecules via non-specific binding. In this article, we report hybrid chemiresistor sensor arrays based on single-walled carbon nanotubes (SWNTs) non-covalently functionalized with six different MPs using the solvent casting technique. The characteristics of MP-SWNTs were investigated through various optical and electrochemical methods, including UV spectroscopy, Raman, atomic force microscopy, current-voltage (I-V), and field-effect transistor (FET) measurement. The proposed sensor arrays were employed to monitor the four VOCs (tetradecene, linalool, phenylacetaldehyde, and ethylhexanol) emitted by citrus trees infected with Huanglongbing (HLB), of which the contents changed dramatically at the asymptomatic stage. The sensitivity to VOCs could change significantly, exceeding the lower limits of the SWNT-based sensors. For qualitative and quantitative analysis of the four VOCs, the data collected by the sensor arrays were processed using different regression models including partial least squares (PLS) and an artificial neural network (ANN), which further offered a diagnostic basis for Huanglongbing disease at the asymptomatic stage. |
format | Online Article Text |
id | pubmed-7237200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72372002020-05-29 Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays Wang, Hui Ramnani, Pankaj Pham, Tung Villarreal, Claudia Chaves Yu, Xuejun Liu, Gang Mulchandani, Ashok Front Chem Chemistry Porphyrins, with or without metal ions (MPs), have been explored and applied in optical and electrochemical sensor fields owing to their special physicochemical properties. The presence of four nitrogen atoms at the centers of porphyrins means that porphyrins chelate most metal ions, which changes the binding ability of MPs with gas molecules via non-specific binding. In this article, we report hybrid chemiresistor sensor arrays based on single-walled carbon nanotubes (SWNTs) non-covalently functionalized with six different MPs using the solvent casting technique. The characteristics of MP-SWNTs were investigated through various optical and electrochemical methods, including UV spectroscopy, Raman, atomic force microscopy, current-voltage (I-V), and field-effect transistor (FET) measurement. The proposed sensor arrays were employed to monitor the four VOCs (tetradecene, linalool, phenylacetaldehyde, and ethylhexanol) emitted by citrus trees infected with Huanglongbing (HLB), of which the contents changed dramatically at the asymptomatic stage. The sensitivity to VOCs could change significantly, exceeding the lower limits of the SWNT-based sensors. For qualitative and quantitative analysis of the four VOCs, the data collected by the sensor arrays were processed using different regression models including partial least squares (PLS) and an artificial neural network (ANN), which further offered a diagnostic basis for Huanglongbing disease at the asymptomatic stage. Frontiers Media S.A. 2020-05-12 /pmc/articles/PMC7237200/ /pubmed/32478033 http://dx.doi.org/10.3389/fchem.2020.00362 Text en Copyright © 2020 Wang, Ramnani, Pham, Villarreal, Yu, Liu and Mulchandani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Wang, Hui Ramnani, Pankaj Pham, Tung Villarreal, Claudia Chaves Yu, Xuejun Liu, Gang Mulchandani, Ashok Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title | Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title_full | Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title_fullStr | Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title_full_unstemmed | Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title_short | Asymptomatic Diagnosis of Huanglongbing Disease Using Metalloporphyrin Functionalized Single-Walled Carbon Nanotubes Sensor Arrays |
title_sort | asymptomatic diagnosis of huanglongbing disease using metalloporphyrin functionalized single-walled carbon nanotubes sensor arrays |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237200/ https://www.ncbi.nlm.nih.gov/pubmed/32478033 http://dx.doi.org/10.3389/fchem.2020.00362 |
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