Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users

Oral contraception (OC) is used by approximately fifty-five million women in the USA alone and is listed as an essential medicine by the World Health Organisation. Altered mood is a common reason for OC cessation. Here we investigate the effects of OC on hormones that are linked to mood. We obtained...

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Autores principales: Garforth, Benjamin, Degnbol, Helle, Terris, Elizabeth T., Zak, Paul J., Winterdahl, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237451/
https://www.ncbi.nlm.nih.gov/pubmed/32427955
http://dx.doi.org/10.1038/s41598-020-64528-w
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author Garforth, Benjamin
Degnbol, Helle
Terris, Elizabeth T.
Zak, Paul J.
Winterdahl, Michael
author_facet Garforth, Benjamin
Degnbol, Helle
Terris, Elizabeth T.
Zak, Paul J.
Winterdahl, Michael
author_sort Garforth, Benjamin
collection PubMed
description Oral contraception (OC) is used by approximately fifty-five million women in the USA alone and is listed as an essential medicine by the World Health Organisation. Altered mood is a common reason for OC cessation. Here we investigate the effects of OC on hormones that are linked to mood. We obtained blood samples from 185 young women (average age 21.2) in two cohorts and tested the effects of OC on plasma levels of oxytocin, adrenocorticotropic hormone (ACTH), estradiol, progesterone and testosterone. We related plasma hormone levels with self-reported measures of mood, well-being and depression. OC-users in both cohorts showed elevated basal oxytocin, lower ACTH, estradiol, progesterone and testosterone compared with non-OC users. Satisfaction With Life Score (SWLS) was higher in OC -users compared to non-OC users, with no differences in the Beck Depression Score (BDI) and Positive And Negative Affect Schedule (PANES). In conclusion, our data show alterations in hormone levels and SWLS in response to OC.
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spelling pubmed-72374512020-05-29 Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users Garforth, Benjamin Degnbol, Helle Terris, Elizabeth T. Zak, Paul J. Winterdahl, Michael Sci Rep Article Oral contraception (OC) is used by approximately fifty-five million women in the USA alone and is listed as an essential medicine by the World Health Organisation. Altered mood is a common reason for OC cessation. Here we investigate the effects of OC on hormones that are linked to mood. We obtained blood samples from 185 young women (average age 21.2) in two cohorts and tested the effects of OC on plasma levels of oxytocin, adrenocorticotropic hormone (ACTH), estradiol, progesterone and testosterone. We related plasma hormone levels with self-reported measures of mood, well-being and depression. OC-users in both cohorts showed elevated basal oxytocin, lower ACTH, estradiol, progesterone and testosterone compared with non-OC users. Satisfaction With Life Score (SWLS) was higher in OC -users compared to non-OC users, with no differences in the Beck Depression Score (BDI) and Positive And Negative Affect Schedule (PANES). In conclusion, our data show alterations in hormone levels and SWLS in response to OC. Nature Publishing Group UK 2020-05-19 /pmc/articles/PMC7237451/ /pubmed/32427955 http://dx.doi.org/10.1038/s41598-020-64528-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Garforth, Benjamin
Degnbol, Helle
Terris, Elizabeth T.
Zak, Paul J.
Winterdahl, Michael
Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title_full Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title_fullStr Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title_full_unstemmed Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title_short Elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
title_sort elevated plasma oxytocin levels and higher satisfaction with life in young oral contraceptive users
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237451/
https://www.ncbi.nlm.nih.gov/pubmed/32427955
http://dx.doi.org/10.1038/s41598-020-64528-w
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