A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems

A facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC(60)) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier’s method for the oxidation of graphite, to produ...

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Autores principales: Zygouri, Panagiota, Spyrou, Konstantinos, Mitsari, Efstratia, Barrio, María, Macovez, Roberto, Patila, Michaela, Stamatis, Haralambos, Verginadis, Ioannis I., Velalopoulou, Anastasia P., Evangelou, Angelos M., Sideratou, Zili, Gournis, Dimitrios, Rudolf, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237490/
https://www.ncbi.nlm.nih.gov/pubmed/32427871
http://dx.doi.org/10.1038/s41598-020-65117-7
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author Zygouri, Panagiota
Spyrou, Konstantinos
Mitsari, Efstratia
Barrio, María
Macovez, Roberto
Patila, Michaela
Stamatis, Haralambos
Verginadis, Ioannis I.
Velalopoulou, Anastasia P.
Evangelou, Angelos M.
Sideratou, Zili
Gournis, Dimitrios
Rudolf, Petra
author_facet Zygouri, Panagiota
Spyrou, Konstantinos
Mitsari, Efstratia
Barrio, María
Macovez, Roberto
Patila, Michaela
Stamatis, Haralambos
Verginadis, Ioannis I.
Velalopoulou, Anastasia P.
Evangelou, Angelos M.
Sideratou, Zili
Gournis, Dimitrios
Rudolf, Petra
author_sort Zygouri, Panagiota
collection PubMed
description A facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC(60)) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier’s method for the oxidation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C(60)) and thereby improve the solubility of the fullerene in polar solvents (e.g. water). The presence of epoxy groups allows for further functionalization via nucleophilic substitution reactions to generate new fullerene derivatives, which can potentially lead to a wealth of applications in the areas of medicine, biology, and composite materials. In order to justify the potential of oxidized C(60) derivatives for bio-applications, we investigated their cytotoxicity in vitro as well as their utilization as support in biocatalysis applications, taking the immobilization of laccase for the decolorization of synthetic industrial dyes as a trial case.
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spelling pubmed-72374902020-05-29 A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems Zygouri, Panagiota Spyrou, Konstantinos Mitsari, Efstratia Barrio, María Macovez, Roberto Patila, Michaela Stamatis, Haralambos Verginadis, Ioannis I. Velalopoulou, Anastasia P. Evangelou, Angelos M. Sideratou, Zili Gournis, Dimitrios Rudolf, Petra Sci Rep Article A facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC(60)) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on the widely known Staudenmaier’s method for the oxidation of graphite, to produce both epoxy and hydroxy groups on the surface of fullerenes (C(60)) and thereby improve the solubility of the fullerene in polar solvents (e.g. water). The presence of epoxy groups allows for further functionalization via nucleophilic substitution reactions to generate new fullerene derivatives, which can potentially lead to a wealth of applications in the areas of medicine, biology, and composite materials. In order to justify the potential of oxidized C(60) derivatives for bio-applications, we investigated their cytotoxicity in vitro as well as their utilization as support in biocatalysis applications, taking the immobilization of laccase for the decolorization of synthetic industrial dyes as a trial case. Nature Publishing Group UK 2020-05-19 /pmc/articles/PMC7237490/ /pubmed/32427871 http://dx.doi.org/10.1038/s41598-020-65117-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zygouri, Panagiota
Spyrou, Konstantinos
Mitsari, Efstratia
Barrio, María
Macovez, Roberto
Patila, Michaela
Stamatis, Haralambos
Verginadis, Ioannis I.
Velalopoulou, Anastasia P.
Evangelou, Angelos M.
Sideratou, Zili
Gournis, Dimitrios
Rudolf, Petra
A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title_full A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title_fullStr A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title_full_unstemmed A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title_short A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
title_sort facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237490/
https://www.ncbi.nlm.nih.gov/pubmed/32427871
http://dx.doi.org/10.1038/s41598-020-65117-7
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