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Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation
Cortical facilitation assessed with triad conditioning transcranial magnetic stimulation has been termed triad-conditioned facilitation (TCF). TCF has been supposed to reflect increased intracortical facilitation (ICF) at short interstimulus intervals (ISI) around 10 ms and an intrinsic rhythm of th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237525/ https://www.ncbi.nlm.nih.gov/pubmed/32322929 http://dx.doi.org/10.1007/s00221-020-05812-z |
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author | Hassan, Shady Safwat Trenado, Carlos Rageh, Tarek Ali Schnitzler, Alfons Groiss, Stefan Jun |
author_facet | Hassan, Shady Safwat Trenado, Carlos Rageh, Tarek Ali Schnitzler, Alfons Groiss, Stefan Jun |
author_sort | Hassan, Shady Safwat |
collection | PubMed |
description | Cortical facilitation assessed with triad conditioning transcranial magnetic stimulation has been termed triad-conditioned facilitation (TCF). TCF has been supposed to reflect increased intracortical facilitation (ICF) at short interstimulus intervals (ISI) around 10 ms and an intrinsic rhythm of the motor cortex at longer ISI around 25 ms. To gain further insight into the pathophysiological mechanism of TCF, we systematically studied the effect of suprathreshold conditioning stimulus (CS) and test stimulus (TS) intensity on TCF. Various CS intensities and TS intensities were used in a triad-conditioning paradigm that was applied to 11 healthy subjects. ISI between pulses were studied between 5 and 200 ms. TCF at 10 ms ISI enhanced with increasing CS intensity but decreased with increasing TS intensity. The duration of facilitation was longer with higher CS intensity. However, TCF at 25 ms ISI could not be elicited with none of the CS and TS intensities addressed here. Our results are consistent with the notion of TCF at short ISI reflecting ICF. The enhanced and prolonged facilitation with increase of CS without additional isolated facilitation at longer ISI suggest a prolongation of ICF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00221-020-05812-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7237525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-72375252020-05-27 Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation Hassan, Shady Safwat Trenado, Carlos Rageh, Tarek Ali Schnitzler, Alfons Groiss, Stefan Jun Exp Brain Res Research Article Cortical facilitation assessed with triad conditioning transcranial magnetic stimulation has been termed triad-conditioned facilitation (TCF). TCF has been supposed to reflect increased intracortical facilitation (ICF) at short interstimulus intervals (ISI) around 10 ms and an intrinsic rhythm of the motor cortex at longer ISI around 25 ms. To gain further insight into the pathophysiological mechanism of TCF, we systematically studied the effect of suprathreshold conditioning stimulus (CS) and test stimulus (TS) intensity on TCF. Various CS intensities and TS intensities were used in a triad-conditioning paradigm that was applied to 11 healthy subjects. ISI between pulses were studied between 5 and 200 ms. TCF at 10 ms ISI enhanced with increasing CS intensity but decreased with increasing TS intensity. The duration of facilitation was longer with higher CS intensity. However, TCF at 25 ms ISI could not be elicited with none of the CS and TS intensities addressed here. Our results are consistent with the notion of TCF at short ISI reflecting ICF. The enhanced and prolonged facilitation with increase of CS without additional isolated facilitation at longer ISI suggest a prolongation of ICF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00221-020-05812-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-04-22 2020 /pmc/articles/PMC7237525/ /pubmed/32322929 http://dx.doi.org/10.1007/s00221-020-05812-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Hassan, Shady Safwat Trenado, Carlos Rageh, Tarek Ali Schnitzler, Alfons Groiss, Stefan Jun Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title | Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title_full | Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title_fullStr | Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title_full_unstemmed | Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title_short | Effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
title_sort | effect of conditioning and test stimulus intensity on cortical excitability using triad-conditioning transcranial magnetic stimulation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237525/ https://www.ncbi.nlm.nih.gov/pubmed/32322929 http://dx.doi.org/10.1007/s00221-020-05812-z |
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