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Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2
Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differenti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237574/ https://www.ncbi.nlm.nih.gov/pubmed/32477372 http://dx.doi.org/10.3389/fimmu.2020.00937 |
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author | Rolph, Daniela Das, Hiranmoy |
author_facet | Rolph, Daniela Das, Hiranmoy |
author_sort | Rolph, Daniela |
collection | PubMed |
description | Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of rheumatoid arthritis in which it has been most extensively studied among the musculoskeletal diseases. The therapies that exist to manage diseases associated with osteoclastogenesis are numerous and diverse. They are varied in their mechanisms of action and in the outcomes they produce. For this review, therapies targeting osteoclasts will be emphasized, though it should be noted that many therapies exist which bolster the action of osteoblasts. A new targeted molecular approach is under investigation for the future potential therapeutic development of rheumatoid arthritis. |
format | Online Article Text |
id | pubmed-7237574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72375742020-05-29 Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 Rolph, Daniela Das, Hiranmoy Front Immunol Immunology Dysregulation of osteoclastic differentiation and its activity is a hallmark of various musculoskeletal disease states. In this review, the complex molecular factors underlying osteoclastic differentiation and function are evaluated. The emerging role of KLF2 in regulation of osteoclastic differentiation is examined, specifically in the context of rheumatoid arthritis in which it has been most extensively studied among the musculoskeletal diseases. The therapies that exist to manage diseases associated with osteoclastogenesis are numerous and diverse. They are varied in their mechanisms of action and in the outcomes they produce. For this review, therapies targeting osteoclasts will be emphasized, though it should be noted that many therapies exist which bolster the action of osteoblasts. A new targeted molecular approach is under investigation for the future potential therapeutic development of rheumatoid arthritis. Frontiers Media S.A. 2020-05-13 /pmc/articles/PMC7237574/ /pubmed/32477372 http://dx.doi.org/10.3389/fimmu.2020.00937 Text en Copyright © 2020 Rolph and Das. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Rolph, Daniela Das, Hiranmoy Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title | Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title_full | Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title_fullStr | Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title_full_unstemmed | Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title_short | Transcriptional Regulation of Osteoclastogenesis: The Emerging Role of KLF2 |
title_sort | transcriptional regulation of osteoclastogenesis: the emerging role of klf2 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237574/ https://www.ncbi.nlm.nih.gov/pubmed/32477372 http://dx.doi.org/10.3389/fimmu.2020.00937 |
work_keys_str_mv | AT rolphdaniela transcriptionalregulationofosteoclastogenesistheemergingroleofklf2 AT dashiranmoy transcriptionalregulationofosteoclastogenesistheemergingroleofklf2 |