Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations

Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines to determine human germline- and tumor-specific deviations from an ancestral-...

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Detalles Bibliográficos
Autores principales: Heredia-Genestar, José María, Marquès-Bonet, Tomàs, Juan, David, Navarro, Arcadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237693/
https://www.ncbi.nlm.nih.gov/pubmed/32427823
http://dx.doi.org/10.1038/s41467-020-16296-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237693/
https://www.ncbi.nlm.nih.gov/pubmed/32427823
http://dx.doi.org/10.1038/s41467-020-16296-4

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