Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons

Hypothalamic neurons show sex differences in neuritogenesis, female neurons have longer axons and higher levels of the neuritogenic factor neurogenin 3 (Ngn3) than male neurons in vitro. Moreover, the effect of 17-β-estradiol (E2) on axonal growth and Ngn3 expression is only found in male-derived ne...

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Detalles Bibliográficos
Autores principales: Cisternas, Carla Daniela, Cabrera Zapata, Lucas Ezequiel, Mir, Franco Rafael, Scerbo, María Julia, Arevalo, María Angeles, Garcia-Segura, Luis Miguel, Cambiasso, María Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237695/
https://www.ncbi.nlm.nih.gov/pubmed/32427857
http://dx.doi.org/10.1038/s41598-020-65183-x

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