nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

Anxiety is common in patients suffering from chronic pain. Here, we report anxiety-like behaviors in mouse models of chronic pain and reveal that nNOS-expressing neurons in ventromedial prefrontal cortex (vmPFC) are essential for pain-induced anxiety but not algesia, using optogenetic and chemogenet...

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Detalles Bibliográficos
Autores principales: Liang, Hai-Ying, Chen, Zhi-Jin, Xiao, Hui, Lin, Yu-Hui, Hu, Ying-Yi, Chang, Lei, Wu, Hai-Yin, Wang, Peng, Lu, Wei, Zhu, Dong-Ya, Luo, Chun-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237711/
https://www.ncbi.nlm.nih.gov/pubmed/32427844
http://dx.doi.org/10.1038/s41467-020-16198-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237711/
https://www.ncbi.nlm.nih.gov/pubmed/32427844
http://dx.doi.org/10.1038/s41467-020-16198-5

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