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Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder
Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237722/ https://www.ncbi.nlm.nih.gov/pubmed/32477180 http://dx.doi.org/10.3389/fpsyt.2020.00381 |
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author | Shao, Xiaojun Zhu, Gang |
author_facet | Shao, Xiaojun Zhu, Gang |
author_sort | Shao, Xiaojun |
collection | PubMed |
description | Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certainly multifactorial and comprehensive. Monoamine neurotransmitter system dysfunction and specific personality traits are independent risk factors for depression and suicide. These factors also demonstrate complex interactions that influence MDD pathogenesis and symptom expression. In this review, we assess these relationships with the aim of providing a reference for the development of precision medicine. |
format | Online Article Text |
id | pubmed-7237722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72377222020-05-29 Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder Shao, Xiaojun Zhu, Gang Front Psychiatry Psychiatry Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certainly multifactorial and comprehensive. Monoamine neurotransmitter system dysfunction and specific personality traits are independent risk factors for depression and suicide. These factors also demonstrate complex interactions that influence MDD pathogenesis and symptom expression. In this review, we assess these relationships with the aim of providing a reference for the development of precision medicine. Frontiers Media S.A. 2020-05-13 /pmc/articles/PMC7237722/ /pubmed/32477180 http://dx.doi.org/10.3389/fpsyt.2020.00381 Text en Copyright © 2020 Shao and Zhu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Shao, Xiaojun Zhu, Gang Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title | Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title_full | Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title_fullStr | Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title_full_unstemmed | Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title_short | Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder |
title_sort | associations among monoamine neurotransmitter pathways, personality traits, and major depressive disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237722/ https://www.ncbi.nlm.nih.gov/pubmed/32477180 http://dx.doi.org/10.3389/fpsyt.2020.00381 |
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