Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modula...

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Detalles Bibliográficos
Autores principales: Zhao, Meng, Xiao, Yi, Otsuka, Satoshi, Nakao, Yoichi, Guo, Yian, Ye, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237762/
https://www.ncbi.nlm.nih.gov/pubmed/32478037
http://dx.doi.org/10.3389/fchem.2020.00410
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author Zhao, Meng
Xiao, Yi
Otsuka, Satoshi
Nakao, Yoichi
Guo, Yian
Ye, Tao
author_facet Zhao, Meng
Xiao, Yi
Otsuka, Satoshi
Nakao, Yoichi
Guo, Yian
Ye, Tao
author_sort Zhao, Meng
collection PubMed
description Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.
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spelling pubmed-72377622020-05-29 Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues Zhao, Meng Xiao, Yi Otsuka, Satoshi Nakao, Yoichi Guo, Yian Ye, Tao Front Chem Chemistry Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity. Frontiers Media S.A. 2020-05-13 /pmc/articles/PMC7237762/ /pubmed/32478037 http://dx.doi.org/10.3389/fchem.2020.00410 Text en Copyright © 2020 Zhao, Xiao, Otsuka, Nakao, Guo and Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Zhao, Meng
Xiao, Yi
Otsuka, Satoshi
Nakao, Yoichi
Guo, Yian
Ye, Tao
Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title_full Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title_fullStr Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title_full_unstemmed Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title_short Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues
title_sort total synthesis and biological evaluation of kakeromamide a and its analogues
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237762/
https://www.ncbi.nlm.nih.gov/pubmed/32478037
http://dx.doi.org/10.3389/fchem.2020.00410
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