The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of...

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Detalles Bibliográficos
Autores principales: McKechnie, Julia L., Blish, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237895/
https://www.ncbi.nlm.nih.gov/pubmed/32464098
http://dx.doi.org/10.1016/j.chom.2020.05.009
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author McKechnie, Julia L.
Blish, Catherine A.
author_facet McKechnie, Julia L.
Blish, Catherine A.
author_sort McKechnie, Julia L.
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description The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.
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spelling pubmed-72378952020-05-20 The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19? McKechnie, Julia L. Blish, Catherine A. Cell Host Microbe Article The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics. Elsevier Inc. 2020-06-10 2020-05-20 /pmc/articles/PMC7237895/ /pubmed/32464098 http://dx.doi.org/10.1016/j.chom.2020.05.009 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
McKechnie, Julia L.
Blish, Catherine A.
The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title_full The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title_fullStr The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title_full_unstemmed The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title_short The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
title_sort innate immune system: fighting on the front lines or fanning the flames of covid-19?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237895/
https://www.ncbi.nlm.nih.gov/pubmed/32464098
http://dx.doi.org/10.1016/j.chom.2020.05.009
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