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Oral Administration System Based on Meloxicam Nanocrystals: Decreased Dose Due to High Bioavailability Attenuates Risk of Gastrointestinal Side Effects
Meloxicam (MLX) is widely applied as a therapy for rheumatoid arthritis (RA); however, it takes far too long to reach its peak plasma concentration for a quick onset effect, and gastrointestinal toxicity has been observed in RA patients taking it. To solve these problems, we designed MLX solid nanop...
Autores principales: | Nagai, Noriaki, Ogata, Fumihiko, Otake, Hiroko, Kawasaki, Naohito |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238067/ https://www.ncbi.nlm.nih.gov/pubmed/32244754 http://dx.doi.org/10.3390/pharmaceutics12040313 |
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