Cargando…

Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in the resection of gastrointestinal mucosal polyps. The aim of this work is the development and evaluation of an innovative polymeric solution containing sodium carboxymethylcellulose and hyaluroni...

Descripción completa

Detalles Bibliográficos
Autores principales: Moles-Aranda, Cristina, Calpena-Campmany, Ana C., Halbaut-Bellowa, Lyda, Díaz-Tomé, Victoria, Otero-Espinar, Francisco J., Morales-Molina, José A., Clares-Naveros, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238115/
https://www.ncbi.nlm.nih.gov/pubmed/32252471
http://dx.doi.org/10.3390/pharmaceutics12040322
_version_ 1783536469718073344
author Moles-Aranda, Cristina
Calpena-Campmany, Ana C.
Halbaut-Bellowa, Lyda
Díaz-Tomé, Victoria
Otero-Espinar, Francisco J.
Morales-Molina, José A.
Clares-Naveros, Beatriz
author_facet Moles-Aranda, Cristina
Calpena-Campmany, Ana C.
Halbaut-Bellowa, Lyda
Díaz-Tomé, Victoria
Otero-Espinar, Francisco J.
Morales-Molina, José A.
Clares-Naveros, Beatriz
author_sort Moles-Aranda, Cristina
collection PubMed
description Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in the resection of gastrointestinal mucosal polyps. The aim of this work is the development and evaluation of an innovative polymeric solution containing sodium carboxymethylcellulose and hyaluronic acid. For this purpose, several mixtures of these two main components, as well as other components such as fructose, citric acid, and zinc, are evaluated in terms of physicochemical and microbiological properties, rheological behavior, extensibility, syringeability, and stability at different storage conditions. Furthermore, the potential production of mucosal elevation and duration is also studied by an ex vivo model using porcine stomach and colon. Results show that the developed polymeric solutions possess optimal values of pH, from 4.58 to 6.63, for their use in the gastrointestinal tract. The formulations exhibit both Newtonian and pseudoplastic behaviors with different viscosity values as a function of their composition. All formulations exhibit high stability properties and no bacterial or fungal growth is detected. MCS01 and MCS05 are the polymeric solutions with the best syringeability results. In this line, MCS05 is the formulation that provides the highest, 2.20 ± 0.18 cm and 1.40 ± 0.11 cm, and longest-lasting, for more than 120 min, elevation effect on porcine submucosal stomach and colon tissues, respectively. Thus, it can be concluded that polymeric solution MCS05 might be considered as a promising tool for use in human EMR and ESD.
format Online
Article
Text
id pubmed-7238115
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72381152020-05-28 Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy Moles-Aranda, Cristina Calpena-Campmany, Ana C. Halbaut-Bellowa, Lyda Díaz-Tomé, Victoria Otero-Espinar, Francisco J. Morales-Molina, José A. Clares-Naveros, Beatriz Pharmaceutics Article Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in the resection of gastrointestinal mucosal polyps. The aim of this work is the development and evaluation of an innovative polymeric solution containing sodium carboxymethylcellulose and hyaluronic acid. For this purpose, several mixtures of these two main components, as well as other components such as fructose, citric acid, and zinc, are evaluated in terms of physicochemical and microbiological properties, rheological behavior, extensibility, syringeability, and stability at different storage conditions. Furthermore, the potential production of mucosal elevation and duration is also studied by an ex vivo model using porcine stomach and colon. Results show that the developed polymeric solutions possess optimal values of pH, from 4.58 to 6.63, for their use in the gastrointestinal tract. The formulations exhibit both Newtonian and pseudoplastic behaviors with different viscosity values as a function of their composition. All formulations exhibit high stability properties and no bacterial or fungal growth is detected. MCS01 and MCS05 are the polymeric solutions with the best syringeability results. In this line, MCS05 is the formulation that provides the highest, 2.20 ± 0.18 cm and 1.40 ± 0.11 cm, and longest-lasting, for more than 120 min, elevation effect on porcine submucosal stomach and colon tissues, respectively. Thus, it can be concluded that polymeric solution MCS05 might be considered as a promising tool for use in human EMR and ESD. MDPI 2020-04-02 /pmc/articles/PMC7238115/ /pubmed/32252471 http://dx.doi.org/10.3390/pharmaceutics12040322 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moles-Aranda, Cristina
Calpena-Campmany, Ana C.
Halbaut-Bellowa, Lyda
Díaz-Tomé, Victoria
Otero-Espinar, Francisco J.
Morales-Molina, José A.
Clares-Naveros, Beatriz
Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title_full Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title_fullStr Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title_full_unstemmed Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title_short Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
title_sort novel polymeric formulation for removal of gastrointestinal polyps by digestive endoscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238115/
https://www.ncbi.nlm.nih.gov/pubmed/32252471
http://dx.doi.org/10.3390/pharmaceutics12040322
work_keys_str_mv AT molesarandacristina novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT calpenacampmanyanac novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT halbautbellowalyda novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT diaztomevictoria novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT oteroespinarfranciscoj novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT moralesmolinajosea novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy
AT claresnaverosbeatriz novelpolymericformulationforremovalofgastrointestinalpolypsbydigestiveendoscopy