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Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy

Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse...

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Autores principales: Avramović, Nataša, Mandić, Boris, Savić-Radojević, Ana, Simić, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238125/
https://www.ncbi.nlm.nih.gov/pubmed/32218326
http://dx.doi.org/10.3390/pharmaceutics12040298
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author Avramović, Nataša
Mandić, Boris
Savić-Radojević, Ana
Simić, Tatjana
author_facet Avramović, Nataša
Mandić, Boris
Savić-Radojević, Ana
Simić, Tatjana
author_sort Avramović, Nataša
collection PubMed
description Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
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spelling pubmed-72381252020-05-28 Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy Avramović, Nataša Mandić, Boris Savić-Radojević, Ana Simić, Tatjana Pharmaceutics Review Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review. MDPI 2020-03-25 /pmc/articles/PMC7238125/ /pubmed/32218326 http://dx.doi.org/10.3390/pharmaceutics12040298 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Avramović, Nataša
Mandić, Boris
Savić-Radojević, Ana
Simić, Tatjana
Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title_full Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title_fullStr Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title_full_unstemmed Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title_short Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
title_sort polymeric nanocarriers of drug delivery systems in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238125/
https://www.ncbi.nlm.nih.gov/pubmed/32218326
http://dx.doi.org/10.3390/pharmaceutics12040298
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