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Antifungal and Antiparasitic Drug Delivery
Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mism...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238172/ https://www.ncbi.nlm.nih.gov/pubmed/32260348 http://dx.doi.org/10.3390/pharmaceutics12040324 |
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author | Torrado, Juan José Serrano, Dolores R. Capilla, Javier |
author_facet | Torrado, Juan José Serrano, Dolores R. Capilla, Javier |
author_sort | Torrado, Juan José |
collection | PubMed |
description | Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue “Antifungal and Antiparasitic Drug Delivery”. |
format | Online Article Text |
id | pubmed-7238172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72381722020-05-28 Antifungal and Antiparasitic Drug Delivery Torrado, Juan José Serrano, Dolores R. Capilla, Javier Pharmaceutics Editorial Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue “Antifungal and Antiparasitic Drug Delivery”. MDPI 2020-04-04 /pmc/articles/PMC7238172/ /pubmed/32260348 http://dx.doi.org/10.3390/pharmaceutics12040324 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Torrado, Juan José Serrano, Dolores R. Capilla, Javier Antifungal and Antiparasitic Drug Delivery |
title | Antifungal and Antiparasitic Drug Delivery |
title_full | Antifungal and Antiparasitic Drug Delivery |
title_fullStr | Antifungal and Antiparasitic Drug Delivery |
title_full_unstemmed | Antifungal and Antiparasitic Drug Delivery |
title_short | Antifungal and Antiparasitic Drug Delivery |
title_sort | antifungal and antiparasitic drug delivery |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238172/ https://www.ncbi.nlm.nih.gov/pubmed/32260348 http://dx.doi.org/10.3390/pharmaceutics12040324 |
work_keys_str_mv | AT torradojuanjose antifungalandantiparasiticdrugdelivery AT serranodoloresr antifungalandantiparasiticdrugdelivery AT capillajavier antifungalandantiparasiticdrugdelivery |