Cargando…

Antifungal and Antiparasitic Drug Delivery

Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mism...

Descripción completa

Detalles Bibliográficos
Autores principales: Torrado, Juan José, Serrano, Dolores R., Capilla, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238172/
https://www.ncbi.nlm.nih.gov/pubmed/32260348
http://dx.doi.org/10.3390/pharmaceutics12040324
_version_ 1783536483859169280
author Torrado, Juan José
Serrano, Dolores R.
Capilla, Javier
author_facet Torrado, Juan José
Serrano, Dolores R.
Capilla, Javier
author_sort Torrado, Juan José
collection PubMed
description Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue “Antifungal and Antiparasitic Drug Delivery”.
format Online
Article
Text
id pubmed-7238172
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72381722020-05-28 Antifungal and Antiparasitic Drug Delivery Torrado, Juan José Serrano, Dolores R. Capilla, Javier Pharmaceutics Editorial Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death. There is a mismatch between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind their poor water solubility, which limits their bioavailability and efficacy. Hence, there is an unmet clinical need to develop vaccines and novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effect by enhancing their dissolution, increasing their chemical potency, stabilising the drug and targeting high concentration of drug to the infection sites. This Editorial regards the ten research contributions presented in the Special Issue “Antifungal and Antiparasitic Drug Delivery”. MDPI 2020-04-04 /pmc/articles/PMC7238172/ /pubmed/32260348 http://dx.doi.org/10.3390/pharmaceutics12040324 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Torrado, Juan José
Serrano, Dolores R.
Capilla, Javier
Antifungal and Antiparasitic Drug Delivery
title Antifungal and Antiparasitic Drug Delivery
title_full Antifungal and Antiparasitic Drug Delivery
title_fullStr Antifungal and Antiparasitic Drug Delivery
title_full_unstemmed Antifungal and Antiparasitic Drug Delivery
title_short Antifungal and Antiparasitic Drug Delivery
title_sort antifungal and antiparasitic drug delivery
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238172/
https://www.ncbi.nlm.nih.gov/pubmed/32260348
http://dx.doi.org/10.3390/pharmaceutics12040324
work_keys_str_mv AT torradojuanjose antifungalandantiparasiticdrugdelivery
AT serranodoloresr antifungalandantiparasiticdrugdelivery
AT capillajavier antifungalandantiparasiticdrugdelivery