Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life?

We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model for eight factors VIII (FVIII) that could estimate individual PK parameters for target...

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Detalles Bibliográficos
Autores principales: Allard, Quentin, Djerada, Zoubir, Pouplard, Claire, Repessé, Yohann, Desprez, Dominique, Galinat, Hubert, Frotscher, Birgit, Berger, Claire, Harroche, Annie, Ryman, Anne, Flaujac, Claire, Chamouni, Pierre, Guillet, Benoît, Volot, Fabienne, Szymezak, Jean, Nguyen, Philippe, Cazaubon, Yoann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238177/
https://www.ncbi.nlm.nih.gov/pubmed/32326156
http://dx.doi.org/10.3390/pharmaceutics12040380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238177/
https://www.ncbi.nlm.nih.gov/pubmed/32326156
http://dx.doi.org/10.3390/pharmaceutics12040380

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