Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechanism clearing acamprosate from the blood in the kid...

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Detalles Bibliográficos
Autores principales: Antonescu, Irina E., Karlgren, Maria, Pedersen, Maria L., Simoff, Ivailo, Bergström, Christel A. S., Neuhoff, Sibylle, Artursson, Per, Steffansen, Bente, Nielsen, Carsten Uhd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238232/
https://www.ncbi.nlm.nih.gov/pubmed/32344570
http://dx.doi.org/10.3390/pharmaceutics12040390

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