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Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods

The aim of this work was to develop an amorphous orlistat-loaded mesoporus silica formulation using the melt-amorphisation by supercritical fluid (MA-SCF) and to investigate the effects of pressure and temperature on the pharmaceutical properties of the developed formulation. In addition, the effect...

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Detalles Bibliográficos
Autores principales:	Park, Heejun, Cha, Kwang-Ho, Hong, Seung Hyeon, Abuzar, Sharif Md, Ha, Eun-Sol, Kim, Jeong-Soo, Kim, Min-Soo, Hwang, Sung-Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238234/ https://www.ncbi.nlm.nih.gov/pubmed/32326103 http://dx.doi.org/10.3390/pharmaceutics12040377

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