Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

(‒)-Sophoranone (SPN) is a bioactive component of Sophora tonkinensis with various pharmacological activities. This study aims to evaluate its in vitro and in vivo inhibitory potential against the nine major CYP enzymes. Of the nine tested CYPs, it exerted the strongest inhibitory effect on CYP2C9-m...

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Detalles Bibliográficos
Autores principales: Zheng, Yu Fen, Bae, Soo Hyeon, Huang, Zhouchi, Chae, Soon Uk, Jo, Seong Jun, Shim, Hyung Joon, Lee, Chae Bin, Kim, Doyun, Yoo, Hunseung, Bae, Soo Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238241/
https://www.ncbi.nlm.nih.gov/pubmed/32272615
http://dx.doi.org/10.3390/pharmaceutics12040328

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