Inflammasomes as Targets for Adjuvants

Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune...

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Autores principales: Ivanov, Konstantin, Garanina, Ekaterina, Rizvanov, Albert, Khaiboullina, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238254/
https://www.ncbi.nlm.nih.gov/pubmed/32235526
http://dx.doi.org/10.3390/pathogens9040252
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author Ivanov, Konstantin
Garanina, Ekaterina
Rizvanov, Albert
Khaiboullina, Svetlana
author_facet Ivanov, Konstantin
Garanina, Ekaterina
Rizvanov, Albert
Khaiboullina, Svetlana
author_sort Ivanov, Konstantin
collection PubMed
description Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.
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spelling pubmed-72382542020-06-02 Inflammasomes as Targets for Adjuvants Ivanov, Konstantin Garanina, Ekaterina Rizvanov, Albert Khaiboullina, Svetlana Pathogens Review Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed. MDPI 2020-03-30 /pmc/articles/PMC7238254/ /pubmed/32235526 http://dx.doi.org/10.3390/pathogens9040252 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ivanov, Konstantin
Garanina, Ekaterina
Rizvanov, Albert
Khaiboullina, Svetlana
Inflammasomes as Targets for Adjuvants
title Inflammasomes as Targets for Adjuvants
title_full Inflammasomes as Targets for Adjuvants
title_fullStr Inflammasomes as Targets for Adjuvants
title_full_unstemmed Inflammasomes as Targets for Adjuvants
title_short Inflammasomes as Targets for Adjuvants
title_sort inflammasomes as targets for adjuvants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238254/
https://www.ncbi.nlm.nih.gov/pubmed/32235526
http://dx.doi.org/10.3390/pathogens9040252
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AT garaninaekaterina inflammasomesastargetsforadjuvants
AT rizvanovalbert inflammasomesastargetsforadjuvants
AT khaiboullinasvetlana inflammasomesastargetsforadjuvants

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