Cargando…

Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease

Cerebral metabolism is tightly regulated and fundamental for healthy neurological function. There is increasing evidence that alterations in this metabolism may be a precursor and early biomarker of later stage disease processes. Proton magnetic resonance spectroscopy ((1)H-MRS) is a powerful tool t...

Descripción completa

Detalles Bibliográficos
Autores principales: Grist, James T, Miller, Jack J, Zaccagna, Fulvio, McLean, Mary A, Riemer, Frank, Matys, Tomasz, Tyler, Damian J, Laustsen, Christoffer, Coles, Alasdair J, Gallagher, Ferdia A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238376/
https://www.ncbi.nlm.nih.gov/pubmed/32153235
http://dx.doi.org/10.1177/0271678X20909045
_version_ 1783536527368781824
author Grist, James T
Miller, Jack J
Zaccagna, Fulvio
McLean, Mary A
Riemer, Frank
Matys, Tomasz
Tyler, Damian J
Laustsen, Christoffer
Coles, Alasdair J
Gallagher, Ferdia A
author_facet Grist, James T
Miller, Jack J
Zaccagna, Fulvio
McLean, Mary A
Riemer, Frank
Matys, Tomasz
Tyler, Damian J
Laustsen, Christoffer
Coles, Alasdair J
Gallagher, Ferdia A
author_sort Grist, James T
collection PubMed
description Cerebral metabolism is tightly regulated and fundamental for healthy neurological function. There is increasing evidence that alterations in this metabolism may be a precursor and early biomarker of later stage disease processes. Proton magnetic resonance spectroscopy ((1)H-MRS) is a powerful tool to non-invasively assess tissue metabolites and has many applications for studying the normal and diseased brain. However, the technique has limitations including low spatial and temporal resolution, difficulties in discriminating overlapping peaks, and challenges in assessing metabolic flux rather than steady-state concentrations. Hyperpolarized carbon-13 magnetic resonance imaging is an emerging clinical technique that may overcome some of these spatial and temporal limitations, providing novel insights into neurometabolism in both health and in pathological processes such as glioma, stroke and multiple sclerosis. This review will explore the growing body of pre-clinical data that demonstrates a potential role for the technique in assessing metabolism in the central nervous system. There are now a number of clinical studies being undertaken in this area and this review will present the emerging clinical data as well as the potential future applications of hyperpolarized (13)C magnetic resonance imaging in the brain, in both clinical and pre-clinical studies.
format Online
Article
Text
id pubmed-7238376
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-72383762020-09-24 Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease Grist, James T Miller, Jack J Zaccagna, Fulvio McLean, Mary A Riemer, Frank Matys, Tomasz Tyler, Damian J Laustsen, Christoffer Coles, Alasdair J Gallagher, Ferdia A J Cereb Blood Flow Metab Review Articles Cerebral metabolism is tightly regulated and fundamental for healthy neurological function. There is increasing evidence that alterations in this metabolism may be a precursor and early biomarker of later stage disease processes. Proton magnetic resonance spectroscopy ((1)H-MRS) is a powerful tool to non-invasively assess tissue metabolites and has many applications for studying the normal and diseased brain. However, the technique has limitations including low spatial and temporal resolution, difficulties in discriminating overlapping peaks, and challenges in assessing metabolic flux rather than steady-state concentrations. Hyperpolarized carbon-13 magnetic resonance imaging is an emerging clinical technique that may overcome some of these spatial and temporal limitations, providing novel insights into neurometabolism in both health and in pathological processes such as glioma, stroke and multiple sclerosis. This review will explore the growing body of pre-clinical data that demonstrates a potential role for the technique in assessing metabolism in the central nervous system. There are now a number of clinical studies being undertaken in this area and this review will present the emerging clinical data as well as the potential future applications of hyperpolarized (13)C magnetic resonance imaging in the brain, in both clinical and pre-clinical studies. SAGE Publications 2020-03-10 2020-06 /pmc/articles/PMC7238376/ /pubmed/32153235 http://dx.doi.org/10.1177/0271678X20909045 Text en © The Author(s) 2020
spellingShingle Review Articles
Grist, James T
Miller, Jack J
Zaccagna, Fulvio
McLean, Mary A
Riemer, Frank
Matys, Tomasz
Tyler, Damian J
Laustsen, Christoffer
Coles, Alasdair J
Gallagher, Ferdia A
Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title_full Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title_fullStr Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title_full_unstemmed Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title_short Hyperpolarized (13)C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
title_sort hyperpolarized (13)c mri: a novel approach for probing cerebral metabolism in health and neurological disease
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238376/
https://www.ncbi.nlm.nih.gov/pubmed/32153235
http://dx.doi.org/10.1177/0271678X20909045
work_keys_str_mv AT gristjamest hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT millerjackj hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT zaccagnafulvio hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT mcleanmarya hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT riemerfrank hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT matystomasz hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT tylerdamianj hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT laustsenchristoffer hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT colesalasdairj hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease
AT gallagherferdiaa hyperpolarized13cmrianovelapproachforprobingcerebralmetabolisminhealthandneurologicaldisease