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Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

BACKGROUND: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. METHODS: Combining multi-modal MR images, biomathematical models, and patient clini...

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Autores principales: Whitmire, Paula, Rickertsen, Cassandra R., Hawkins-Daarud, Andrea, Carrasco, Eduardo, Lorence, Julia, De Leon, Gustavo, Curtin, Lee, Bayless, Spencer, Clark-Swanson, Kamala, Peeri, Noah C., Corpuz, Christina, Lewis-de los Angeles, Christine Paula, Bendok, Bernard R., Gonzalez-Cuyar, Luis, Vora, Sujay, Mrugala, Maciej M., Hu, Leland S., Wang, Lei, Porter, Alyx, Kumthekar, Priya, Johnston, Sandra K., Egan, Kathleen M., Gatenby, Robert, Canoll, Peter, Rubin, Joshua B., Swanson, Kristin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238585/
https://www.ncbi.nlm.nih.gov/pubmed/32429869
http://dx.doi.org/10.1186/s12885-020-06816-2
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author Whitmire, Paula
Rickertsen, Cassandra R.
Hawkins-Daarud, Andrea
Carrasco, Eduardo
Lorence, Julia
De Leon, Gustavo
Curtin, Lee
Bayless, Spencer
Clark-Swanson, Kamala
Peeri, Noah C.
Corpuz, Christina
Lewis-de los Angeles, Christine Paula
Bendok, Bernard R.
Gonzalez-Cuyar, Luis
Vora, Sujay
Mrugala, Maciej M.
Hu, Leland S.
Wang, Lei
Porter, Alyx
Kumthekar, Priya
Johnston, Sandra K.
Egan, Kathleen M.
Gatenby, Robert
Canoll, Peter
Rubin, Joshua B.
Swanson, Kristin R.
author_facet Whitmire, Paula
Rickertsen, Cassandra R.
Hawkins-Daarud, Andrea
Carrasco, Eduardo
Lorence, Julia
De Leon, Gustavo
Curtin, Lee
Bayless, Spencer
Clark-Swanson, Kamala
Peeri, Noah C.
Corpuz, Christina
Lewis-de los Angeles, Christine Paula
Bendok, Bernard R.
Gonzalez-Cuyar, Luis
Vora, Sujay
Mrugala, Maciej M.
Hu, Leland S.
Wang, Lei
Porter, Alyx
Kumthekar, Priya
Johnston, Sandra K.
Egan, Kathleen M.
Gatenby, Robert
Canoll, Peter
Rubin, Joshua B.
Swanson, Kristin R.
author_sort Whitmire, Paula
collection PubMed
description BACKGROUND: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. METHODS: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). RESULTS: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). CONCLUSION: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
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spelling pubmed-72385852020-05-29 Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients Whitmire, Paula Rickertsen, Cassandra R. Hawkins-Daarud, Andrea Carrasco, Eduardo Lorence, Julia De Leon, Gustavo Curtin, Lee Bayless, Spencer Clark-Swanson, Kamala Peeri, Noah C. Corpuz, Christina Lewis-de los Angeles, Christine Paula Bendok, Bernard R. Gonzalez-Cuyar, Luis Vora, Sujay Mrugala, Maciej M. Hu, Leland S. Wang, Lei Porter, Alyx Kumthekar, Priya Johnston, Sandra K. Egan, Kathleen M. Gatenby, Robert Canoll, Peter Rubin, Joshua B. Swanson, Kristin R. BMC Cancer Research Article BACKGROUND: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. METHODS: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). RESULTS: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). CONCLUSION: Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes. BioMed Central 2020-05-19 /pmc/articles/PMC7238585/ /pubmed/32429869 http://dx.doi.org/10.1186/s12885-020-06816-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Whitmire, Paula
Rickertsen, Cassandra R.
Hawkins-Daarud, Andrea
Carrasco, Eduardo
Lorence, Julia
De Leon, Gustavo
Curtin, Lee
Bayless, Spencer
Clark-Swanson, Kamala
Peeri, Noah C.
Corpuz, Christina
Lewis-de los Angeles, Christine Paula
Bendok, Bernard R.
Gonzalez-Cuyar, Luis
Vora, Sujay
Mrugala, Maciej M.
Hu, Leland S.
Wang, Lei
Porter, Alyx
Kumthekar, Priya
Johnston, Sandra K.
Egan, Kathleen M.
Gatenby, Robert
Canoll, Peter
Rubin, Joshua B.
Swanson, Kristin R.
Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title_full Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title_fullStr Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title_full_unstemmed Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title_short Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
title_sort sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238585/
https://www.ncbi.nlm.nih.gov/pubmed/32429869
http://dx.doi.org/10.1186/s12885-020-06816-2
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