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Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5

Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3–5 chronic kidney disease (CKD). Totally 205 participants were enrolled. Fasting blood sample were checked and serum leptin were measured by en...

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Autores principales: Lu, Jing-Wun, Chi, Po-Jui, Lin, Yu-Li, Wang, Chih-Hsien, Hsu, Bang-Gee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238868/
https://www.ncbi.nlm.nih.gov/pubmed/32403968
http://dx.doi.org/10.1080/21623945.2020.1764799
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author Lu, Jing-Wun
Chi, Po-Jui
Lin, Yu-Li
Wang, Chih-Hsien
Hsu, Bang-Gee
author_facet Lu, Jing-Wun
Chi, Po-Jui
Lin, Yu-Li
Wang, Chih-Hsien
Hsu, Bang-Gee
author_sort Lu, Jing-Wun
collection PubMed
description Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3–5 chronic kidney disease (CKD). Totally 205 participants were enrolled. Fasting blood sample were checked and serum leptin were measured by enzyme immunoassay. Aortic stiffness was measured as the carotid–femoral pulse wave velocity (cfPWV). 73 (35.6%) of 205 patients showed cfPWV >10 m/s were defined as aortic stiffness group. Compared with the remaining patients, the aortic stiffness group had high prevalence of diabetes mellitus, older age, higher waist circumference, body fat mass, systolic blood pressure, fasting glucose, and higher serum leptin level. In multivariable logistic regression analysis the independent predictors of cfPWV >10 m/s included leptin levels (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.027–1.095, P < 0.001), age (OR: 1.064, 95% CI: 1.033–1.096, P< 0.001), and systolic blood pressure (OR: 1.021, 95% CI: 1.006–1.037, P = 0.006). Multivariable forward stepwise linear regression analysisshowed a positive association between log-transformed leptin levels and log-cfPWV (β = 0.192, adjusted R(2) change = 0.042, P = 0.001). Thus, aortic stiffness is positively correlated with serum leptin levels in patients with stage 3–5 CKD. Abbreviations: BUN, blood urea nitrogen; cfPWV, carotid–femoral pulse wave velocity; CI, confidence interval; CKD, chronic kidney disease; Cre, creatinine; DBP, diastolic blood pressure; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; SBP, systolic blood pressure; TCH, total cholesterol; TG, triglycerides
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spelling pubmed-72388682020-06-01 Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5 Lu, Jing-Wun Chi, Po-Jui Lin, Yu-Li Wang, Chih-Hsien Hsu, Bang-Gee Adipocyte Research Article Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3–5 chronic kidney disease (CKD). Totally 205 participants were enrolled. Fasting blood sample were checked and serum leptin were measured by enzyme immunoassay. Aortic stiffness was measured as the carotid–femoral pulse wave velocity (cfPWV). 73 (35.6%) of 205 patients showed cfPWV >10 m/s were defined as aortic stiffness group. Compared with the remaining patients, the aortic stiffness group had high prevalence of diabetes mellitus, older age, higher waist circumference, body fat mass, systolic blood pressure, fasting glucose, and higher serum leptin level. In multivariable logistic regression analysis the independent predictors of cfPWV >10 m/s included leptin levels (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.027–1.095, P < 0.001), age (OR: 1.064, 95% CI: 1.033–1.096, P< 0.001), and systolic blood pressure (OR: 1.021, 95% CI: 1.006–1.037, P = 0.006). Multivariable forward stepwise linear regression analysisshowed a positive association between log-transformed leptin levels and log-cfPWV (β = 0.192, adjusted R(2) change = 0.042, P = 0.001). Thus, aortic stiffness is positively correlated with serum leptin levels in patients with stage 3–5 CKD. Abbreviations: BUN, blood urea nitrogen; cfPWV, carotid–femoral pulse wave velocity; CI, confidence interval; CKD, chronic kidney disease; Cre, creatinine; DBP, diastolic blood pressure; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; SBP, systolic blood pressure; TCH, total cholesterol; TG, triglycerides Taylor & Francis 2020-05-13 /pmc/articles/PMC7238868/ /pubmed/32403968 http://dx.doi.org/10.1080/21623945.2020.1764799 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Jing-Wun
Chi, Po-Jui
Lin, Yu-Li
Wang, Chih-Hsien
Hsu, Bang-Gee
Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title_full Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title_fullStr Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title_full_unstemmed Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title_short Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
title_sort serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3–5
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238868/
https://www.ncbi.nlm.nih.gov/pubmed/32403968
http://dx.doi.org/10.1080/21623945.2020.1764799
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