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High Throughput Discovery of Functional Protein Modifications by Hotspot Thermal Profiling

Mass spectrometry has revolutionized the ability to study posttranslationally modified proteoforms from biologic samples, yet we still lack methods to systematically predict, or even prioritize, which modification sites may perturb protein function. Here we describe a proteomic method to detect the...

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Detalles Bibliográficos
Autores principales:	Huang, Jun X., Lee, Gihoon, Cavanaugh, Kate E., Chang, Jae W., Gardel, Margaret L., Moellering, Raymond E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238970/ https://www.ncbi.nlm.nih.gov/pubmed/31384043 http://dx.doi.org/10.1038/s41592-019-0499-3

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